I started taking deprenyl and I love the effects I am experiencing. More motivation, greater pleasure in activities, more confidence, slightly heightened sociability, perceived memory enhancement, and less fatigue. I am taking 1.25 mg per day.
However, as I dig more into the experiences of others I see that quite a few people experience pretty bad withdrawal symptoms, which are just the opposite: sadness, hopelessness, apathy, etc. Some experience this even on low doses, while at least one person reportedly took 7.5mg per day for long stretches and never experienced any withdrawal symptoms.
I do not want to have withdrawal symptoms. I won't be able to function. Is there a surefire way to avoid them? I see some people recommend taking weekends off, but will that really do any good considering the half-life of MAO type B inhibition is about 40 days?
Related question: What is the best way to research cognitive enhancers? My method basically comes down to googling any concerns that come into my mind and trying to find articles with scientifically backed claims. However I sometimes worry that I am going to miss something important. I feel like I should be doing some required reading that gives me a solid pharmacological knowledge base before experimenting. Is that necessary if I am really not all that interested in pharmacology, but more so just improving my mind and life?
Full Version: Avoiding Deprenyl Withdrawals
Humm, probably I am not knowledgeable enough but I would say everything comes with a price.
If you develop undesired effects, unless is something that can be fixed controlling your diet (tyramine) the only option will be to ditch it.
If you develop undesired effects, unless is something that can be fixed controlling your diet (tyramine) the only option will be to ditch it.
QUOTE(Jakare @ May 27, 2012, 03:57 PM) 
Humm, probably I am not knowledgeable enough but I would say everything comes with a price.
If you develop undesired effects, unless is something that can be fixed controlling your diet (tyramine) the only option will be to ditch it.
My question though is about avoiding withdrawal symptoms after the drug has been ditched, not avoiding possible side effects while on it.
Sorry my fault. Such withdrawal symptoms are the result of a downregulation on membrane receptors or upregulation of certain enzymes. They will return to normal after sometime but I donīt know how to avoid such symptoms.
An option will be to slowly reduce the dose by half week after week instead of dicht it directly. That would mitigate (maybe to the point of not having any at all) any withdrawal symptoms. However the process will take longer.
An option will be to slowly reduce the dose by half week after week instead of dicht it directly. That would mitigate (maybe to the point of not having any at all) any withdrawal symptoms. However the process will take longer.
QUOTE(Jakare @ May 28, 2012, 05:20 AM)
Sorry my fault. Such withdrawal symptoms are the result of a downregulation on membrane receptors or upregulation of certain enzymes. They will return to normal after sometime but I donīt know how to avoid such symptoms.
An option will be to slowly reduce the dose by half week after week instead of dicht it directly. That would mitigate (maybe to the point of not having any at all) any withdrawal symptoms. However the process will take longer.
I will try that, thanks. Does down regulation / up regulation occur with all drugs?
Is there a certain length of time that is recommended or just plain sensible to limit your intake to, and to permit between periods of administration? Cycle on for ___, cycle off for ____?
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