to swing the other way, I would hope stablon to be a means to changing the dependence of psychonauts. Maybe it is a sweet lie?

Yes, Stablon is very cheap in Turkey, it is 60tabs for 30.26YTL = $17.86 in a regular pharmacy.
The available online drugstores are money hungry swindlers!!!

I have a big profit/advantage buying Stablon (for the price above) because I am from origin Turkish (living in the Netherlands) and buy it from a regular pharmacy in the town where my parents come from.

If I can get over my airplane anxiety I am going on vacation this summer to Turkey and gonna talk to the pharmacist about the idea to start a (cheap) online drugstore. If it is allowed by law he might consider doing it, then it's a win-win situation.

That's cheap. The other online stores are probably just importing them from Turkey. A turkish based pharmacy would be a great idea then.

Kinda funny. You probably would have to be on stablon in order to get on an airplane to Turkey, just so you can get more stablon.

What little I dug up on pubmed says the opposite. The ones doing the actual abuse, are either drug users, or people bordering on suicide.

Tolerance compared to other substances seems pretty good though. There's no way you could up the dose on a street drug that same way you can on stablon and expect to live.

does that mean that it's something safe to abuse?

Safer relative to other drugs, and the personality of the user who's taking them. If you have a history of abuse, no drug is really safe for you. You'd be substituting one substance over another, but the behavior would still be there.

Is there any concensus on how long Stablon takes to work?

Several weeks perhaps - like other ADs - to muck with shit downstream from just serotonin: genes, neuronal changes, etc.

Granted you probably FEEL something within taking the first dose, but any understanding of real therepeutic help?

ALSO: Was Tianeptine BANNED by the FDA, or was it just never brought to the U.S.? Banned would connotate something bad with it, never brought to the FDA just makes sense (being off patent, big $$ to pass U.S. testing, etc)

20 questions 20 questions.

How does tianeptine/Stablon work? No one really knows. So the story below will soon be superseded. Tianeptine is neuroprotective via multiple neurochemical and cellular mechanisms. When an organism is under stress, or perceives itself under stress, the hypothalamus secretes corticotropin-releasing hormone/factor (CRH/CRF). CRH/CRF in turn increases secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary. ACTH in turn stimulates the release of glucocorticoids from the adrenal cortex. Persistent, uncontrolled physical and psychosocial stress causes excess cortisol secretion from the adrenal glands. Excess cortisol causes dendritic shrinkage in the hippocampus and a contrasting growth of dendrites in the lateral amygdala. These stress-induced changes tend to lower mood; they can cause clinical depression in the genetically vulnerable. Current evidence suggests that tianeptine acts to prevent and even reverse stress-induced neural damage, promoting both neuronal survival and synaptic plasticity. Sustained use of tianeptine tends to "normalise" the hypothalamic-pituitary-adrenal (HPA) system. Tianeptine reduces basal and stress-evoked activity of the HPA, helping its users cope in a stressful environment. Treatment with tianeptine inhibits corticosterone-induced gene transcription. Stress-induced increases in plasma ACTH, and corticosterone levels are diminished. So too is basal activity of corticotropin-releasing factor (CRF) neurons and their sensitivity to stress. Prolonged tianeptine use also reduces some forms of stress-induced apoptosis ("programmed cell-death"), notably in the temporal cortex and dentate gyrus of the hippocampus. At the molecular level, tianeptine exerts profound effects on the glutamate system. The amino acid glutamate serves as the main excitatory neurotransmitter in the brain. Its excitatory action is mediated by via multiple receptor subtypes. The three main subtypes of glutamate-gated ion channel are kainate, ampa, and N-methyl-D-aspartate (NMDA). Tianeptine prevents overstimulation of AMPA/kainate type glutamate receptors in the hippocampus that regulate Ca2+ entry into the nerve cell; excess Ca2+ entry into nerve cells is toxic. Tianeptine also modulates the NMDA glutamate receptors. NMDA receptors for glutamate play a critical role in mediating the functional and intracellular effects of stress. Tianeptine reportedly targets the phosphorylation-state of glutamate receptors in the hippocampus, "normalising" stress-induced changes in the amplitude ratio NMDA glutamate receptor to AMPA/kainate glutamate receptor-mediated excitatory post-synaptic currents. Selective glutamate receptor antagonists, including sub-anaesthetic doses of the dissociative anaesthetic ketamine, can act as analgesics and neuroprotective antidepressants, despite dose-limiting side-effects. Their mind-altering properties deter wider clinical psychiatric use. Tianeptine, on the other hand, is an analgesic and antidepressant that lacks psychotomimetic

(Don't know if this is the answer to your question otherwise click on the source below)




Tianeptine was first synthesised in 1981[?] by French researchers Antoine Deslandes and Michael Spedding. It has been developed and marketed since the late 1980s as the antidepressant Stablon by secretive, privately-owned Servier, the innovative French drug giant. Tianeptine is sold in Europe, Latin America and Asia. It is not marketed in North America because its patent has expired. To gain a US product license, a raft of costly new clinical trials would be needed by the FDA. Unfortunately, American regulators are habitually sceptical of the calibre of European medical science. Even after FDA approval, tianeptine/Stablon could be sold only cheaply due to generic competitors. Commercially, this might not seem an insoluble problem: structurally, tianeptine may be considered a modified tricyclic, and patentable analogues of tianeptine do exist, notably hetero[2,1]benzothiazepine derivatives. But if and when any such analogues will be commercialised is uncertain. No evidence exists that they are therapeutically superior to tianeptine. Another option might exploit how tianeptine sold as Stablon (etc) is a racemate; the l-isomer is more therapeutically active than its molecular sister. The design of single-isomer "chiral" drugs allows corporate patent lawyers to extend the patent life of old medicines. Thus tired SSRI antidepressant citalopram/Celexa was relaunched in 2002 as expensive new s-citalopram/Lexapro; and patent-expired modafinil/Provigil will soon be relaunched as expensive new r-modafinil/Nuvigil. This route hasn't been pursued yet with Stablon. In fact tianeptine may finally reach the USA branded not as an antidepressant, but in the guise of a treatment of Irritable Bowel Syndrome (IBS). For in 2004 Vela Pharmaceuticals registered a patent for the use of tianeptine to treat IBS. In March 2006 Pharmos Corporation acquired Vela. Tianeptine for IBS is now in "late-preclinical development" (mid-2006). If and when a medicine gains a US product license, physicians can then prescribe it "off-label" for whatever they see fit, including depression. But this prospect is several years away at best.




More @ source: http://www.tianeptine.com/

Alrighty. I've finally tried it.

I can't say it has a major impact at all on me with a single dose (12.5mg).
At x3 the dose you do feel its benefits.

I intentionally put myself in a high stress environment to see how I'd react, and it does help at a higher dose. At a regular dose I felt as uncomfortable as I would on my usual self.
Very different than how ssri works though. I don't feel doped up, or lethargic. I'm also not very aware of the usual anxiety triggers. No other weird immediate side effects to report either.

I do have to say that this probably benefits people with major anxiety/depression disorders, and not people with mild anxiety problems (such as myself). I'll likely not continue its use when I'm done with this batch. It's too expensive.

I'll report back in a couple of weeks when it runs out.

Alrighty, I've ALSO just finally tried it.

Today is my 7th day, taking the recommended 12.5 mg of Stablon, 3x daily.

In my experience, I don't have any noticeable change within 15 minutes or whatever that some users have reported. Also, no experience of a noticeable increase in joy, or euphoria, or anything positive upon taking it.

What I do notice is that my brain seems to become more restricted, or constricted, or rigid, or like being put in a straight-jacket. Not terrible like I've had with some SSRIs, but noticeable enough.

The positive: Is that in the last 7 days I've noticeably had an increase in mood and brain function. So while during the day taking the doses I don't feel terrifically better after taking the doses, and do feel overall better, most noticeably in the morning, and late at night (when the drug is not in me) ---- so there's the rub, it doesn't feel better when the drug is in me, but only when it's not, and overall, I feel better.

So...hopefully things continue to get better. I don't like the idea of having a constricted mind during the day, so that I can feel better at night/morning, but we'll see.

I'll also report back in a week, for a 2-week update.

* dry mouth (38% vs 20%)
* constipation (19% vs 15%)
* dizziness/syncope (23% vs 13%)
* drowsiness (17% vs 10%)
* postural hypotension (8% vs 3%)
* Insomnia (7% vs 20%)

That sounds like fun

I've tried many SSRI's and in comparison, Stablon is the best in terms of lack of sides. Not to mention there are no sexual side effects to this med (which are all too common amongst all seratonin-affecting meds). It can be slightly sexually enhancing via dopaminergic enhancing effects.

I never received any sides from it myself, none that were noticeable, at any dose I might add, except for some sleep issues in the first week or two. But these all go away as the system adjusts.

I would have to say this is by far my favorite anti-anxiety / anti-depression / smart drug ever, by far.

I can't wait until I move to Europe next yr so I can have this med prescribed to me.

right, the list of side effects and stats dont mean anything because in real-life reality every person with experience says: "SSRIs and the others feel horrible and torture me, stablon makes me feel better and is very clean"

so lists of side effects and such are separated from reality and dont tell anything practical. its like listing the side effects of ginseng and listing the side effects of ritalin when in real life reality one does nothing and the other has an effect on energy. the inserts dont say anything about real life reality and the true effect of the drugs. if a person was born yesterday and say ginseng and ritalin package inserts, they wouldnt be able to tell anything. thats how bogus package inserts are in some regards

that list of side effects is versus another drug and from the Tianeptine wiki:

"Tianeptine was both studied for short-term (3 month) and long-term treatment (12 months) and equally well tolerated. The studies encompassed 1,300 to nearly 3,000 patients each.

Side effects are as follows (Amitriptyline vs Tianeptine):"


and also against a placebo, the placebo is usually around 10% for all those anyway

What do your Stablon tablets look like?

Has anyone tried cutting them and taking part of one?

The brain restriction description makes sense given the way it affects glutamate (assuming what someone about wrote about its effects on the brain is correct).

Is it similar to Lamictal/Neuronton/Topamax or Namenda in the way it makes your brain feel constricted? (I've described the feeling I get from Lamictal as feeling as though my brain were in bubble wrap.)

That would not be good. Now if there was a way to double them, then that would be better =D This med is under-dosed

I know that Stablon can negatively impact your cortisol and throw your HPA system out of balance. I took it and wasn't too impressed by it. In fact, I found it harder to relate to people and focus/concentrate while on it.

I'd check your cortisol level before taking this.

That's the point, cortisol is meant for short fight or flight situations only and literally destroys the hippocampus, the place where memories are formed.

Hello!

I suppose there are a number of factors that can play into whether cortisol is doing this sort of thing or not. Stress and anxiouty without exercise could possibly lead to build-up (that is if the stress and anxiousty aren't due to the adrenals underproducing due to a genetic condition or due to adrenal fatigue).

You know alot more about this than me but here's my impression:

I know cortisol is usually supposed to be quite high when you get up in the morning (as it builds up during sleep until it gets to a point where one wakes up) and is supposed to get lower as the day winds down. Cortisol is just one of those things that you don't want an excessive amount of (kind of like a lot of things). However, the marketing behind this compound labels cortisol as the dark hormone or whatever. This made me buy into it as a great nootropic to try out. However, in terms of direct benefit, at least for myself, I couldn't wait for the drug to wear off after taking it. I still have an unused packet at the moment but this is one compound I'm not particularly thrilled with after trying it out. If cortisol needs to be limited I wonder if there are more indirect ways towards doing so? I know blood sugar regulation and eating the right diet (limit foods with low gylcemic value) could help steady energy levels. Plus, there are other drugs out there that may indirectly limit cortisol (maybe by giving someone a sense of well being) as opposed to having a primary or secondary direct effect on cortisol (some may be able to derive some ideas from this link http://en.wikipedia.org/wiki/Cortisol).

The whole Serotonin enhancement theory sounds great on paper. Maybe there'll be some other compounds that come out soon that give some sort of entactogenic effect (minus the dangers and potency's of entactogenic compounds of course), which is kind of what I initially thought when I first read the word "serotonin enhancement"...

Hi!

I think the answer may lie in finding out why exercise increases cortisol, but also increases hippocampal function. Maybe not by limiting cortisol itself, but help whatever protective mechanisms are in place in the hippocampus during exercise?

Cortisol increases ACTH, and a fragment of that hormone has memory enhancing properties and has been turned into a drug analog called Semax.

Serotonin is tricky as it has opposite affects depending on the brain region and receptor type... but this drug seems to have the most promise as a serotonin based memory enhancer so it looks good on paper.

I have not taken it as you have but I will in the future, I am not stressed but maybe it will increase the effect of another memory enhancer because of its unique method of action.

I agree. If the effects of stablon provided the same effects as an SSRI minus the side effects, this would be very interesting. The effects upon taking it just didn't impress me much. There are a number of people that actually prefer SSRI's (some have described these drugs as having more of a "Comfort zone" aspect to them). SSRI comparison chart:
http://74.125.95.132/search?q=cache:d-zzF7...n&ct=clnk&gl=us

You're right about Serotonin having different targets in the human brain. For instance 5HT3 (a type of serotonin receptor certain kinds of SSRI's seem to inhibit to impair acetylcholine) is one serotononin receptor that if antagonised could improve memory (since 5ht3 is co-localized with acetylcholine receptors; this co-localization is done so that serotonin hitting 5ht3 will lower the amount of acetylcholine).

Other than inhibitors (SSRI's), the other types of drugs out there (called entactogens) are very dangerous but offer an interesting mode of action on Serotonin as well. There are even some stimulants out there that are no longer sold in the US (like fenfluramine) that act mainly as an agonist towards serotonin. The problem with these mechanisms is that there's a very, very high toxicity (for your traditional entactogens like MDMA which is very unsafe and never could be taken more than a couple times a year if that) or high toxicity.

As a result, I think the Serotonin Enhancement concept is a promising/interesting route to take towards developing possible future compounds besides just Stablon.

Certain entheogens (metabolites from various plants such as mesembrine) may have interesting serotonin applications towards future compounds as well.

I wonder if it would be possible to increase serotonin without sedation, limiting acetylcholine (this is possible), or avoid direct interference with cortisol (or other parts of the HPA system). Certain natural mechanisms, like the exercise mechanism for how the HPA system is activated, how serotonin is increased through sunlight, or others could definitely play a role in terms of developing novel strategies for serotonin enhancement without some of the road bumps I named above.

Hope this rambling makes sense to anybody.

I have adrenal fatigue (cortisol insufficiency due to long term chronic stress and lifestyle factors), and stablon still felt great when I took it before being treated with low dose cortisol therapy.

Right now I am currently taking low dose hydrocortisone (5-10 mg per day) and things are only better all around. More energy, more clarity and cognitive abilities are up.

Do you still take Stablon while taking hydrocortisone?

No I haven't been but I'm about to start another course of it. I like to cycle it's use for maximum efficacy. I can report back after starting again. Going to start my regular protocol soon of 25mg 3x daily (6 tabs daily over 3 doses). Will taper up to this dose over a week, maybe 4 days.

Here is another interesting discussion about cortisol:

http://www.mindandmuscle.net/forum/index.php?showtopic=37846

One time I fantasized about getting a price quote for half a kilogram (seems to be the minimum order size) in powder form from a Chinese supplier and discreetly reselling it but the whole idea seems so lofty, cumbersome and undoubtedly expensive that it can be tenably rejected outright. But for perspective, that would be 40,000 tablets worth. It would be nice to afford to take higher doses of this stuff and to be able to provide it affordably to other people as well. However, the thought of going to federal "pound me in the ass" prison is a tad bit dissuading. This is the same reason I gave up on custom synthesizing pure amineptine within the states.

hey as this is the biggest stablon feedback on the net, i thought i would give my experience
i have no depression or ever have i ordered stablon thinking it would enhance my mood.
i took 3 tabs a day with meals for 3-4 weeks absolutely did nothing. so i heard u need to take alot because servier recommended dose is to low so i took 15 tabs at once. in about 20 mins i was red hot sweating like a pig after another 20 mins i was just hot like u just got out of a bath.
between 40mins to 3-4 hours
my mood was dulled with a slight headache
i had the constant feeling of vomitting for about 4-5 hours
slurred speech unable to hold proper conversation noticable to anothers
no change in anxiety some as always. not confident not shy
this was the biggest thing! first let me say im the most mild mannered person very easy going
this stuff made me so aggressive i think if my personality was diifferent i would have hurt or killed someone
not aggressive towards myself if you understand towards others my dad was using my tools in the garage which he does from time to time i had the strong desire to kick him in the head and take my tools,
u have to get i never feel aggression ever i hit my toe on the table leg and my blood boiled i really wanted to smash the place up
many thoughts of hurting others.
the next couple of days
my memory is dreadful still is after 1 week i cant remember what i had for tea yesterday every day!
saw some friend i used to know for year but havent seen for 6 months couldnt remember there names
dont take this thinking it will enhance ur mood it wont in my experience

See? I told you its a real med with real effects compared to other meds which are fake fraud. anyone who tries it is just going to post here like insum did and say thats true.

youre an idiot, you went from 1 tablet straight to 15. the max you can take at once without side effects is 6 to 8 depending on the person

this is obviously some sort of dumbass propaganda post,

u go awy, ok u? bye byezzzz

It's obviously a teenager with too much time (and daddy's credit card) in his hands.
Glad no one can OD on this stuff, or it would've made news by now.

@tenbolone

ROFL.. is it possible u 'liked' the effect of 3 tabs but wanted more of that feeling and took 15? If so, u have a low tolerance to addiction, if u did the same with coffee u would get sick also, so obviously u can't blame the drug.


@mk-ultra

When will u post a new update on your experience with Stablon?

btw @ Tenbolone



This is what I said earlier in this thread and you have confirmed it.

I ended up ordering more, and I might order more if I find a cheaper source ;-)
At x3 daily dosage, a pack of 30 tabs proved too little to make a good test run for me.
It seems I feel the effects better when taken with meals. Other than feeling less anxious a half hour after intake I have nothing else to report. No major side effects to report. No dependency either, I went two weeks without it before receiving more. One thing worth mentioning is that it kills deprenyl's effect, and PEA as well. I should've avoided this combo, but I had forgotten I had taken stablon earlier in the day.
Wished I had more to report but the benefits I'm getting are mild and subtle. With that said, I prefer that over drugs that would make me feel weirded out after the effects subside. I'm not sure if that makes sense, but that's just me.

Do people find it best when taken with fatty foods? Is it lipophilic?

Might taste nasty, but has anyone also tried taking it sublingually?

It definitely enhances cognition at the proper dose. When I was taking 6 per day, I was always sharp and positive, but never edgy. People who try it at 3per day, might be wasting their time and money with this drug. It's commonly believed to be under-dosed.

Yeah. There's a reason why it's coated. It doesn't taste any bitter than deprenyl though.
The effects weren't as strong as with taken with foods.
Same thing when taken with water alone in the morning. Not as strong of an effect.

PM if you've found a cheaper source of this. At $40usd per 30 tabs it doesn't seem likely that I'd continue its use.

PM sent. $40usd for 60 tabs of aussie generic, $53usd for 60tabs of regular EU stablon

I have a question about Stablon interaction for any users or people who may know:

Is it safe to take stablon while on sam-e? I have been taking sam-e to aid with depression and under-methylation, also been taking P5P/Green Tea extract with this to help with dopamine.

Thinking of starting another round of stablon again but I want to continue my sam-e usage.

Basically looking for any interactions with this combo:

Stablon - 2x12.5mg tabs 3x daily
+
Sam-e (800mg active pd)
Methyl Folate
Methyl b-12
P5P (100-150mg pd)
Green Tea 50% Extract (500-1500mg pd)

After reading about Stablon on another forum a few months ago i bought it and took the suggested dose (3x12.5mg) and did not feel anything at all. I had more or less written it off. It is only after coming across this forum where it has been mentioned that a higher dose may work better. I have taken 2x 12.5mg approximately 2 hours ago and feel subtle feelings of overall well being and a gentle peace. Its a great feeling.

Can anybody tell me if it is safe to take Stablon alongside either Selegiline or Modafinil (or alongside both)?

Thank you to everyone for your very useful advice and feedback on your experiences.

@ papa t

Yes, it is save to take Stablon with Modafinil. (did it too)
Stablon with Selegiline, I don't know.

Thanks for that 'YoungS' . Ive tried stablon with modafinil the last couple of days and it works good. Does anybody know if Selegiline is safe to take with Stablon. If yes what dosage?

Apparently there's some crazy video claiming that shooting tianeptine with a needle will cause the body to rot. There's a very graphic video at this site called nothingtoxic that shows some guys hand rotting away. This is so far out I don't know what to make of this.

I can post the link if you'd like but a simple google search could turn up this video. Anybody hear of this? What's going on?!

I don't know what to do right now.
I am depressed for the fifth or sixth time in my life, so it keeps comming back.
At the moment i am using Lithium and Citalopram.
Lithium works a bit, but Citalopram is not working.

Yesterday i went to my docter, i asked him for a different medication.
I was thinking of Wellbrutin, because it works different than the other meds.
I did never heard off Stablon yet.

But he didn't agree with that.
He raised the Citalopram from 30mg to 40mg and said to wait a month to see if it works, and if it will not he will raise it up to 50mg and 60mg.
On the worst scenario we will after 4 months(!) found out that it not works.

After reading all the positive things about Stablon.
I am thinking of quitting Citalopram and try Stablon.
Do you guys really think the result of Stablon will be better that other medication for depression?

Hi Dreamer,

In your situation, if the depression comes and goes, then it might be good to try/take Stablon. As you might have read in this topic, Stablon acts right away (15/30min.) when taken so you will notice results in days. You can stop with Stablon whenever you want, without the nasty drug withdrawal side-effects.

Thanks for your reply YoungS.
I have sent you a PM.

*Don't* stop the citalopram quickly. Go higher on the citalopram, as your doctor suggests if you've had any response to it at all. Modafinil +SSRI can be very helpful, unless you're on the lithium for bipolar. Check out modafinil dot com for info on how modafinil + SSRI increases serotonin in the prefrontal cortex.

If you haven't had any response to citalopram, you might try adding a slight bit of a TCA like clomipramine (say, 50mg) to the mix. There is no better antidepressant than clomipramine, though its side effects in higher doses make it hard for people to take. But in lower doses in combination with other drugs it can be very helpful.

All of these are legal in the US.

Depression is a horrible thing. I know too well.

Consensus on taking Stablon with SAMe?

Since stablon is so expensive, I am looking to get the most out of it. SAMe/stablon conjunctive therapy may help people who are naturally low in serotonin and dopamine, making this drug work better. I just want to be sure this idea is safe.

Tianeptine (Stablon) will have a gradual effect but rather quickly (2 to 3 weeks). Dosage is 3 per day (12.5 mg). Yes, it is to be taken daily. However, each person responds differently, such is my case. I've been taking it for nine years.
For the initial three years it had rather magical effects on me when experimenting and taking all three tablets together upon awakening at 5:30 am. A neuroenhancer galore and dissipater of depression within 45 minutes. This happened after 2 weeks of taking it, so it is possible that the serum levels have to reach their peak and be maintained, but this not proved.
There is scarce mention of this effect in the literature but it appears to happen in a very small percentage of users (less than 5%). Again, this are all guesstimates as there seems to be an odd absence of reporting or documentation. The manufacturer, Servier Laboratoires, to my knowledge, is silent in this respect, which makes for pondering... It has been through nine years completely non toxic for me and has produced no noticeable side-effects..., none at all.
Tianeptine (Stablon) is purported to be an SSREnhancer and not an SSRInhitor and thus reduces the amount of Serotonine available in the synapse—the diametrically opposite effect of the SSRIs. Some have said that its effect comes from a modulation in some manner of the inflammatory cytokines

You mention that taking Stablon with foods produces the strongest effects. I've taken Stablon at 3x at a time for nine years but have always taken alone on an empty stomach with as little water as possible.
I take all three immediately upon awakening (5:30 am) and wait in bed until well enough to get up, usually 45 min--it produced a pronounced neuroenhancing and “activating” effect plus complete elimination of all depression--but it most salient effect was elimination all of the considerable malaises (sickness syndrome).
However, after the first three years most of these effects began disappearing, some sort of tolerance appeared.
I have continued using Stablon for the following five years but had to take repeated dosages during the day— yet the effect was still much less and it has continued decreasing until now hardly any is left.
My query is regarding taking Stablon with food or LIPIDS. I am new to these forums and I ask how much confirmation is there to taking with foods being better that with little water? I don't recall that that being my experience, but then I have tried that so few times—if any. I ask in particular the taking with lipids, fats; specifically which fats—how? Bacon?
If a person cannot get up from bed upon awakening because of extreme malaises (body illnesses) and does not have assistance, it would be difficult to add freshly prepared food to the dosage. Instead of with little water it could be a small amount of olive oil or coconut oil. Not being much familiar with forums, can you tell me if you or “anyone reading this post” has read about the efficacy when mixing with lipids? I am in search for a way to augment the current effect to what it was during the initial three years.
As information for all I add that Servier Laboratories (of Stablon) is starting to market a new antidepressant named Valdoxan (Agomelatine).
As I understand it just coming out in Britain. This is a very novel antidepressant. It is a Melatonergic in action, it increases (agonist) the activity of the receptors for Melatonin at M1 and M2 and decreases (antagonist) the activity of the receptor for Serotonin 5HT2c. Novartis obtained the license to market it in the U.S. and has submitted it to the FDA where, I believe, it lingers until their patent on their own antidepressant (SSRI) expires. Since it is from Servier, the innovator with Survector and Stablon there is hope that it may also be effective, but that remain to be seen—if it is effective it may “run of the mill” and NOT have neuroenhancing or activating properties. I haven’t being able to locate a source at all yet, so would appreciate knowing if someone has…