Antiviral activity of piracetam, Y.M. centifanto, tulane university school of medicine, new orleans, louisiana (USA)
Antiviral Research, Volume 17, Supplement 1, March 1992, Page 114
here is the paper, it is only half a page long:
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Antiviral Activity of Piracetam, Y.M. Centifanto, Tulane University School
of Medicine, New Orleans, Louisiana (USA)
The effect of Piracetam (2-oxo-i pyrrodiline acetamide), a nootropic
drug, on herpes simplex virus (HSV) infections was examined. We found that
HSV replication on Vero cells was totally inhibited by the drug, even when
added 6 hr pi. The drug needed continuous contact with the infected cell
to exert its effect, suggesting a virustatic mode of action. Three types
of experiments were conducted for the in vivo studies: i) In the hairless
guinea pig model of herpetic recurrent disease, cellophane stripping of a
previously infected area induces the appearance of recurrent herpetic
lesions. Topical application of a 10% Piracetam to these areas inhibited
lesion formation by 70% as compared to the control; 2) Using the same system,
the drug at 20 mg/kg was given either orally or in the drinking water,
prevented lesion formation; 3) Female guinea pigs were infected in the
genital area with HSV-I (333) strain. After the primary lesions subsided,
and in the period of spontaneous recurrent lesions, the animals were given
oral doses of Piracetam for three consecutive weeks. We found that the
drug was effective in reducing the number of recurrent lesions on the
treated animals by more than 50%. Additional experiments with different
doses are now in progress. It is important to note that Piracetam has a
more definite inhibitory action on recurrent lesions as compared to a very
mild action on primary disease. We theorize that this beneficial effect on
the prevention of recurrent lesions may be related to their reported
cholinergic functions.
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Unfortunately the "Additional experiments" cannot be found. None of the other papers released by Y.M. Centifanto contained any mention of piracetam.
There is probably no research on this because there are more effective antivirals, and no incentive to fund research because piracetam is not owned by one company.
Do racetams prevent the common cold?! We'll never know.