Besides taking the amino acid, tyrosine, which is a precursor to dopamine synthesis, what drugs increase dopamine synthesis, what drugs increase dopamine release (lots of these, almost all recreational drugs), and what drugs inhibit dopamine breakdown (besides l-deprenyl)? Also, what about targetting different receptor subtypes of the dopamine receptor, D1 and D2?

Precursor:
L-Phenylalanine
L-Tyrosine
L-DOPA

Receptor:
Bromocriptine
Piribedil

MAO-B inhibitor:
Deprenyl
Rasagiline


Nice pic:

I haven't heard of trivastal retard 50 before. Do you need a prescription? You'd think they'd come up with a cooler name than trivastal RETARD 50.

Haha yeah its not the best name but its only available in France as far as i know.

Since tyrosine and phenylalanine were mentioned, what would be good doses to use of N-Acetyl-L-Tyrosine and D-Phenylalanine to use? I've been working up to 800mg NAL-Tyrosine without much effect...

now were talkin! DOPAMINE

never try permax, that agonist is NASTY. bromo is so so. i want to try the agonist mirapex but i doubt that would be of much value. i have selegiline but dont like it very much, i just take quater pills here and there as a very strong neuroprotective agent until it runs out.

Unfortunately the best dopaminergics are probably stablon, amineptine, and certain opioids

Production of amineptine ceased and its impossible to get, so forget about it. this is supposed to be a real clean and good feeling drug, many doctors reported it was the only thing to work for their patients(0). the real reason it was banned? who knows. sometimes its seems medicine is AGAINST the treatment of depression and prefers to push inferior drugs that make you feel numb or bad.

Stablon chemically similar to amineptine and is classified as a serotonin reuptake enhancer that lowers extracellular serotonin(1). one abstract i read says its not a dopamine reuptake inhibitor like amineptine is even though they are similar (2). either way it is less likely to get banned as an SSRE. I took the drug and it has a clean subtle dopaminergic feel to it. This could be from the fact that serotonin has an attenuating effect on dopamine so lowering serotonin adds dopamine transmission(4). Stablon seems to be very non-toxic compared to most drugs. this drug does not even interact with P-450 or any liver enzymes. it metabolizes the same way fatty acids in food do! beta-oxidation(5). one woman was on 150 tablets per day and suffered no toxic effects(6). another man was on 240 tablets per day (3)

Mu Opioid Agonists have an effect of increasing dopamine transmssion in the reward pathways but are of course subject to a bad tolerance and dependance. They also slow bowel movements

Tone

(0) http://www.amineptine.com
(1) http://www.biopsychiatry.com/tianepvparox.html
(2) http://www.biopsychiatry.com/tian.htm
(3) http://www.biopsychiatry.com/tianeptine-addict.htm
(4) Tianeptine increases the extracellular concentrations of dopamine in the nucleus accumbens by a serotonin-independent mechanism. http://www.ncbi.nlm.nih.gov/entrez/query.f...0&dopt=Abstract
(5) http://www.servier.com/pro/Neurosciences/s...blon_faq_01.asp
(6) http://www.biopsychiatry.com/tianeptineexcess.htm

For me its seems 1-2 Grams of N-Acetyl-L-Tyrosine at once is needed to feel an effect. For D-Phenylalanine 1-3 Grams has quite a noticeable effect in feeling stimulated yet in a good mood. I would suggest using the lowest dose needed to obtain an effect.

Tone what are your thoughts on Rasagiline?

it has to be better, no L-(meth)amphetamine metabolites. id like to try that one but i cant afford that! what is it $300 for 28 tablets? i doubt it would that good of a mood booster or antidepressant though

Production may have ceased, but it is not impossible to get. :-) In my country, amineptine (Survector) is still available through remaining supplies. My pharmacist can still get it.

It's excellent for non-neurotic depression. I wouldn't take it if you suffer from significant anxiety as it could exacerbate that due to its stimulating effects upon the adrenergic system. I tried a low dose (1/4 tablet) of 25mg per day and after a few days I began to have more panic attacks, so it wasn't worth it for me, although it was a fast-acting (i.e. acting within 7 days) antidepressant. No sexual side effects to speak of and I would say it did boost my libido somewhat.

Stablon (tianeptine) would be better suited for those with neurotic depression, or any depression for that matter.

http://en.wikipedia.org/wiki/Tianeptine

http://en.wikipedia.org/wiki/Amineptine

How does PEA (PhenylEthylAmine) compare to D-Phenylalanine?

Phenylalanine is a precursor to dopamine...Man all of this time I was chewing gum in class I never knew I was just trying to relieve myself of the depression caused by school

In what regard?

QUOTE

Phenylalanine is a precursor to dopamine...Man all of this time I was chewing gum in class I never knew I was just trying to relieve myself of the depression caused by school

L-DOPA is the direct precursor to Dopamine.

L-Phenylalanine can be converted into L-Tyrosine of which is converted into L-DOPA.

D-Phenylalanine does not appear to convert into L-Tyrosine but rather Phenylethylamine.