In my experience, boosting ACh is a good thing to do, whether it be through nicotine stimulation of nicotinic acetylcholine receptors, or through acetylcholinesterase inhibitors, which keeps acetylcholine in the synaptic cleft longer before being degraded, thereby allowing it to act for longer durations at acetylcholine receptors.

There are two types of acetylcholine receptors, muscarinic and nicotinic. You can easily stimulate the nicotinic receptors by taking some nicotine patch or smoking a cigarette. What about muscarinic, how do you stimulate these using materials that may be purchased and that are safe?

I guess my general question is, what drugs will potentiate ACh transmission, either by increasing its synthesis, release, or by inhibiting its enzymatic breakdown? I want a list of such drugs and information on what types of cholinergic receptors they act on, how safe they are, where they can be purchased and for how much, and any other information regarding drug effects and possible interactions.

muscarinic:
ALC
Nebracetam

nicotinic:
Galantamine
nicotine

Galantamine versus nicotine? What is the difference in effects between these two? Can you take galantamine?

Galantamine is far safer than nicotine and not addictive.

Galantamine also inhibits AChE as well for a dual effect on memory.


I like it for motivation and memory personally.

4-24 mg daily with food.

how can galantamine not be addictive whereas nicotine is so much so?

Different compounds.

Ashwaghanda has cognition-enchancing effects which is attributed to its ACh transmission-enchancing effect. See this study: http://www.ncbi.nlm.nih.gov/entrez/query.f...5&dopt=Abstract

Administration of Shilajit led to reduced acetylcholinesterase staining, restricted to the basal forebrain nuclei including medial septum and the vertical limb of the diagonal band. Systemic application of the defined extract from Withania somnifera, however, led to differential effects on AChE activity in basal forebrain nuclei: slightly enhanced AChE activity was found in the lateral septum and globus pallidus, whereas in the vertical diagonal band AChE activity was reduced following treatment with sitoindosides VII-X and withaferin-A. These changes were accompanied by enhanced M1-muscarinic cholinergic receptor binding in lateral and medial septum as well as in frontal cortices, whereas the M2-muscarinic receptor binding sites were increased in a number of cortical regions including cingulate, frontal, piriform, parietal and retrosplenial cortex. The drug-induced increase in cortical muscarinic acetylcholine receptor capacity might partly explain the cognition-enhancing and memory-improving effects of extracts from Withania somnifera observed in animals and humans.

what is the best type of choline to take with piracetam?

CDP-Choline
Alpha GPC choline
phosphytidyl choline
or any other?

CDP-Choline if going for an antiaging brain aging effect.
Alpha GPC if you are looking for a more noticeable effect.

Can you explaint to me what Nebracetam is, Mirage? I've found out myself that nebracetam has been developed by boehringer ingelheim in the early nineties under the name web 1881 fu and that it is said to potentiate ampa receptor function. But afaik it is not sold at the moment by any company and i haven't found out anything regarding its sideffects.

It's a unique Piracetam analog with effects mostly unrelated to racetams. It has been shown to be relatively safe and effective however it is still somewhat new. It is sold in the US by one or more of the Nootropic suppliers.