SSRIs and tricyclics are terrible drugs for depression. Safe and effective drugs with better mechanisms like amineptine are banned ( http://www.amineptine.com )
TV ads show animated diagrams of serotonin being reuptake but we know the serotonin hypothesis of depression is wrong because those drugs take weeks to kick in and when they do they end up making a lot of people worse and dulling other people. Also stablon has the exact opposite effect by enhancing reuptake of 5-HT, and lowers extra cellular serotonin levels yet is an antidepressant as well. (serotonin has an attenuating effect on dopamine transmission) The studies say it is "just as effective as SSRIs", but if you ask anyone in real life who has tried it they will tell you its very much better than SSRIs and a night and day difference.
The ever so vital dopamine and opiodergic pathways are ignored in drug design to combat dysphoria syndrome/depression. Depression continues to be an epidemic. People who are very dysfunctional from depression rarely, if any, take antidepressants and suddenly feel good and increase in functioning.
my opinion, poor drug design is policy, not ignorance.
