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> adenosine receptors implicated in some undefined neurological disease
post Oct 11, 2012, 08:20 PM
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I've been experiencing some very strange symptoms over the last couple of years and I was hoping someone could help me try to understand the science behind the problem I'm having both for curiousity's sake and also because I wouldn't mind getting better either. No doctor I've talked to thus far has had any clue what I've been talking about, and it's seemed that I've been more knowledgable on the subject than themselves.

What would cause you to feel good only during caffeine withdrawal OR during sleep deficit, and terrible at all other times?

The commonality between each of these situations is increased adenosine acitvity.

i.e. If you are sleep deprived more adenosine adheres to adenosine receptors and during caffeine withdrawal the number of adenosine receptors is upregulated so adenosine adheres to adenosine receptors more easily.
So just to make things crystal clear, under normal circumstances where I haven't consumed caffeine for a couple of weeks or more and consequently receptor levels are normal OR I have had sufficient sleep and I feel well rested I feel extremely bad. So during times of lower adenosine activity I feel terrible, and during times of increased adenosine activity I feel good (albeit slighty tired if Iím experiencing sleep deficit).

I have a strong suspicion that when I'm feeling bad, there's decreased blood flow to my brain because when I take vasodilators I feel much better.Also, adenosine functions as a vasodilator when it adheres to adenosine receptors (I think), so it's adenosine which is performing this vasodilation function when sleep deprived or experiencing caffeine withdrawal. Additionally, taking vasoconstrictors will make me feel much worse.
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