![]() ![]() |
| cane714 |
May 21, 2012, 08:21 AM
Post
#1
|
|
Newbie ![]() Group: Basic Member Posts: 8 Joined: May 16, 2012 Member No.: 34243 |
I start a new job 6/4/12. I have been experimenting with Deprenyl for about a week and was worried after hearing you can get a positive hit for Methamphetamines.
I'm guessing i need to stop the Deprenyl and try to flush my System. Is there a best way to do this? Are there any other Nootropics or Supplements that will give a false positive? Thanks for the input |
| Jakare |
May 24, 2012, 01:02 PM
Post
#2
|
![]() Demi-God ![]() ![]() ![]() ![]() ![]() Group: Basic Member Posts: 581 Joined: Feb 24, 2010 Member No.: 32635 |
I looked at this issue time ago, lets see if I can recapitulate some info:
-Selegiline is metabolized into l-methamphetamine. http://en.wikipedia.org/wiki/Selegiline QUOTE L-amphetamine and L-methamphetamine Selegiline is partly metabolized to l-methamphetamine, one of the two enantiomers of methamphetamine in vivo.[25] A characteristic metabolic pattern was noted, exemplified by a ratio of l-methamphetamine to l-amphetamine of about 2.8.[26] These stereoisomers are considered significantly less psychoactive and have little abuse potential in contrast to their D-isomers.[27] The stimulatory effect on locomotor activity and dopamine synthesis may be contributed to by the action of l-methamphetamine, a once thought to be inactive metabolite.[25] This locomotor effect at therapeutic doses was not apparent in comparison to placebo, but both l-amphetamine and l-methamphetamine had positive effects on genetic expression for memory enhancement in rats and other animals.[28] This metabolic action may cause persons taking selegiline to test positive for amphetamine and or methamphetamine on drug screening tests. -Some drug test meassure up only for D-methamphetamine (the one found in ilegal drugs) while others will react in presence of both. -The half life of l-methamphetamine depends upon the dose, fluid intake, excretion, and urinary pH. http://www.healthy.net/scr/article.aspx?Id=2503 http://drug.addictionblog.org/how-long-do-...in-your-system/ After reading that I would not be confident on passing a drug test with less than 4-5 days after last exposure. Make it a week just in case, It would be a drama to give a positive on something important just for taking a supplement. It can be something really hard to explain without a prescription I imagine. Rasagiline does not give any false positives but is dearer. |
| cane714 |
May 25, 2012, 10:13 AM
Post
#3
|
|
Newbie ![]() Group: Basic Member Posts: 8 Joined: May 16, 2012 Member No.: 34243 |
I looked at this issue time ago, lets see if I can recapitulate some info: -Selegiline is metabolized into l-methamphetamine. http://en.wikipedia.org/wiki/Selegiline QUOTE L-amphetamine and L-methamphetamine Selegiline is partly metabolized to l-methamphetamine, one of the two enantiomers of methamphetamine in vivo.[25] A characteristic metabolic pattern was noted, exemplified by a ratio of l-methamphetamine to l-amphetamine of about 2.8.[26] These stereoisomers are considered significantly less psychoactive and have little abuse potential in contrast to their D-isomers.[27] The stimulatory effect on locomotor activity and dopamine synthesis may be contributed to by the action of l-methamphetamine, a once thought to be inactive metabolite.[25] This locomotor effect at therapeutic doses was not apparent in comparison to placebo, but both l-amphetamine and l-methamphetamine had positive effects on genetic expression for memory enhancement in rats and other animals.[28] This metabolic action may cause persons taking selegiline to test positive for amphetamine and or methamphetamine on drug screening tests. -Some drug test meassure up only for D-methamphetamine (the one found in ilegal drugs) while others will react in presence of both. -The half life of l-methamphetamine depends upon the dose, fluid intake, excretion, and urinary pH. http://www.healthy.net/scr/article.aspx?Id=2503 http://drug.addictionblog.org/how-long-do-...in-your-system/ After reading that I would not be confident on passing a drug test with less than 4-5 days after last exposure. Make it a week just in case, It would be a drama to give a positive on something important just for taking a supplement. It can be something really hard to explain without a prescription I imagine. Rasagiline does not give any false positives but is dearer. Thank you for the reply |
| Jakare |
May 25, 2012, 12:11 PM
Post
#4
|
![]() Demi-God ![]() ![]() ![]() ![]() ![]() Group: Basic Member Posts: 581 Joined: Feb 24, 2010 Member No.: 32635 |
Your welcome! I like to help when I can.
|
| alisha99 |
Jul 18, 2012, 02:21 AM
Post
#5
|
|
Aspiring ![]() ![]() Group: Basic Member Posts: 57 Joined: Jul 12, 2012 Member No.: 34366 |
Selegiline is the best medicine to improve memory and improve brain functions. It helps to increase dopamine levels in brain.
|
| Tone |
Jul 18, 2012, 09:22 AM
Post
#6
|
![]() Overlord ![]() ![]() ![]() ![]() Group: Basic Member Posts: 410 Joined: Mar 03, 2006 From: Chicago Member No.: 4916 |
The MAOI Inhibition of deprenyl is far, far longer than the time it causes false stimulant positives. The molecule bonds covalently to MAO-B, and the rest of it left over metabolize and is eliminated within a few days. the effect of it is far longer than it being detectable.
In otherwords you can still be pretty MAO-B inhibited with its "leftovers" long since metabolized and eliminated to not cause false positives. A week to be safe |
![]() ![]() |
| Lo-Fi Version | Time is now: 22nd May 2013 - 08:04 AM |