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> Legal alternatives in Canada?
hamster
post Apr 10, 2012, 05:38 PM
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Hello,
I'm new to this forum which seems awesome in every aspect.
I'm on my look for a legal alternative to classic study drugs such as ritalin.

I have found ADDRENA. Havent been able to obtain that much information about it but it sure seems potent according to their website.

Is there other legal alternatives "over the counter"?
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KoolK3n
post Apr 10, 2012, 05:40 PM
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QUOTE(hamster @ Apr 10, 2012, 08:38 PM) *

Hello,
I'm new to this forum which seems awesome in every aspect.
I'm on my look for a legal alternative to classic study drugs such as ritalin.

I have found ADDRENA. Havent been able to obtain that much information about it but it sure seems potent according to their website.

Is there other legal alternatives "over the counter"?


Didn't you just make an account earlier today called "HamsterDance"?
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hamster
post Apr 10, 2012, 05:43 PM
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QUOTE(KoolK3n @ Apr 10, 2012, 05:40 PM) *

QUOTE(hamster @ Apr 10, 2012, 08:38 PM) *

Hello,
I'm new to this forum which seems awesome in every aspect.
I'm on my look for a legal alternative to classic study drugs such as ritalin.

I have found ADDRENA. Havent been able to obtain that much information about it but it sure seems potent according to their website.

Is there other legal alternatives "over the counter"?


Didn't you just make an account earlier today called "HamsterDance"?

haha, actually not but it I guess "hamster" is a trendy name at the moment wink.gif
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mban
post Apr 10, 2012, 09:59 PM
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Hi Hamster,

If you are looking for something to boost your dopamine levels (as Ritalin does) you could try a dose of 500mg - 2 grams of L-Tyrosine per day. Start with a low dose in the morning, and only increase by slight amounts if you don't get the desired effects. I also suggest taking 2-3 days off each week so that you don't develop a tolerance to it. Don't take it within 5 hours of going to bed or it will affect your sleep quality. Also, more does not always equal better. There is an inverted U type relationship between dopamine production in the brain and performance.

Also make sure that you are getting enough vitamins and minerals that are required as co-factors for the conversion of the l-tyrosine into dopamine (take a multivitamin).

Further, make sure to do some reading on the internet of the possible interactions and side effects of taking tyrosine.

Cheers,

mban
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hamster
post Apr 13, 2012, 08:59 AM
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QUOTE(mban @ Apr 10, 2012, 09:59 PM) *

Hi Hamster,

If you are looking for something to boost your dopamine levels (as Ritalin does) you could try a dose of 500mg - 2 grams of L-Tyrosine per day. Start with a low dose in the morning, and only increase by slight amounts if you don't get the desired effects. I also suggest taking 2-3 days off each week so that you don't develop a tolerance to it. Don't take it within 5 hours of going to bed or it will affect your sleep quality. Also, more does not always equal better. There is an inverted U type relationship between dopamine production in the brain and performance.

Also make sure that you are getting enough vitamins and minerals that are required as co-factors for the conversion of the l-tyrosine into dopamine (take a multivitamin).

Further, make sure to do some reading on the internet of the possible interactions and side effects of taking tyrosine.

Cheers,

mban


Thanks for the info. Where Can I buy it? Is it available in Montreal?
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mban
post Apr 13, 2012, 04:00 PM
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QUOTE

Thanks for the info. Where Can I buy it? Is it available in Montreal?


I get mine from the US from nutrabio dot com or purebulk dot com. I am sure you could find other places online too. L-tyrosine is simply an amino acid so it is not illegal or hard to obtain. Your local health food store or workout supplement store may have some as well. I think purebulk is cheaper right now if you take into account shipping prices.
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kaleshnikov
post May 07, 2012, 01:00 AM
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You won't derive much of a cognitive benefit from Thyrosine as the dopamine that does get created will not cross the blood/brain barrier, but it will linger around in other dopamine receptors through out your body. Basically, you increase your chances of all the shitty side effects of Adderall/Ritalin, without getting much of the cognitive benefit.
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mban
post May 07, 2012, 03:35 PM
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QUOTE(kaleshnikov @ May 07, 2012, 03:00 AM) *

You won't derive much of a cognitive benefit from Thyrosine as the dopamine that does get created will not cross the blood/brain barrier, but it will linger around in other dopamine receptors through out your body. Basically, you increase your chances of all the shitty side effects of Adderall/Ritalin, without getting much of the cognitive benefit.


Dopamine does not cross the BBB, but both L-tyrosine and L-Dopa DO cross the BBB. Likewise, most tyrosine that is ingested will not be converted into dopamine within the blood, but instead will be taken up into cells to be used for general protein synthesis (note: only a portion of tyrosine that passes through the BBB will be used in the dopamine synthesis pathway). SOME of the l-tyrosine within the blood will undergo hydroxylation to become L-DOPA, then L-DOPA can undergo decarboxylation to become dopamine, but this process takes time and significant amounts of tyrosine and L-DOPA make it into the CNS. The small amount of dopamine formed from LOW DOSE tyrosine (under 1 gram) in the peripheral circulation cause little to no side effects. Another portion of the supplemented tyrosine will act as a building block for the production of thyroxine, which could cause worsening of hyperthyroidism or Grave's Disease if already present.

Further, the way that tyrosine acts in supporting dopamine production is HUGELY different than the mechanism of action of the dopamine/noradrenaline re-uptake inhibitors (Ritalin/Adderall). The production of dopamine from tyrosine in the CNS occurs on an "as needed" basis (i.e. synaptic dopamine levels will not be largely increased in the synapse unless a task is mentally or physically demanding and requires higher release of dopamine).

So in summary:

Does some tyrosine get converted into dopamine in the blood? Yes
Is it significant enough to cause similar side effects to Ritalin? Not really
Does tyrosine raise CNS levels of dopamine when needed? Yes
Does it benefit cognition if a higher level of dopamine is required? Yes

All this being said, if the first poster is looking for something as a study aid, then tyrosine can help them out when mentally stressed. If on the other hand the poster has full blown ADHD (which is completely different than just wanting a dopamine boost), then they should talk to their doctor about getting medications specifically for the ADHD.
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