most enhancing substance Options

[Yoder]

For those of you that extensively research neuroscience and Nootropics, which drugs/supplements (pharmaceutical, herbal, everthing)do you think has the most to offer for cognitive enhancement? No matter the side effects and more research that needs to be done..

[Flex]

Dexedrine. Galantamine and deprenyl are pretty solid.

[Yoder]

Dexedrine. Galantamine and deprenyl are pretty solid.

What about drugs in the making? Which do you think have the most to offer in the near-future for normal, healthy adults?

[Flex]

Honestly, I don't think many will have much of anything to offer the world. Mostly more harm than good. That said, neutraceuticals are probably going to be the most effective.

This is the company I would keep my eye on:
http://www.sirtrispharma.com/about.html

[Jhana]

The following is a quote I came across from a user on DMT-Nexus:

"By far and away the 4 best mind enhancements are, exercise, diet, sleep, and meditation. These 4 will do far more than any drug can do for you. If you are not doing at least 3 of them then you need to take on those tasks before even considering a drug. If your body is not getting the proper water, food and rest it is not getting what it needs to operate effectively and no drug is going to make up for a lack in nutrients and recovery. Any beneficial effects will only serve to weaken you further when not on the drug as it will over tax a already weakened system. One of my associates had excellent results from modafinil but after 3 days of taking it he was so run down and exhausted he could barely get around the house. He simply did not eat well and outright hated to exercise. The result was that the drugs worked for a short while however they took their toll in the end as his bodily resources were quickly run dry."

Good stuff.

That being said.
As far as exotic consumables for cognitive and energy enhancement, I've found the following to be beneficial:

Piracetam
Aniracetam
DMAE
Lecithin
CDP-Choline (if you can afford it)
Inositol

A good complete food based whole protein with all amino-acids

Chlorella
Spirulina
Maca

L-Carnitine
Acetyl-L-Carnitine
Alpha-Lipoic-Acid (said to synergize with the Carnitines)

DL-Phenylalanine
L-Tyrosine

L-Taurine
L-Arginine
Beta-Alanine

L-Tryptophan (before bed on empty stomach)

SAM-e
TMG / DMG

Special fatty acids:
DHA
CLA
The Omega-3's
Ground flax seeds

A good multi-B vitamin (time release with a well balanced dosage)
Sulbutiamine
Methylcobalamin
A good mineral stack: magnesium, potassium, calcium, zinc, etc.
Vitamin D, E, C

A high quality Green or Oolong tea brewed correctly
Green tea extract
Raw cocoa beans or 85%+/-

I've heard good things about CoQ-10 & Idebenone, but haven't tried them due to high cost.


By far, the number 1 best enhancer of all...
Meditation: Vipassana + Samatha
Supported by exercise and a natural whole diet
&
N,N-DMT and a few of the other substituted Tryptamine's & Phenethylamine's

For those of you that extensively research neuroscience and Nootropics, which drugs/supplements (pharmaceutical, herbal, everthing)do you think has the most to offer for cognitive enhancement? No matter the side effects and more research that needs to be done..

[Cephalon]

Diet & exercise are definately important. But I can only recognize an effect on my "wellbeing".

What gave me good effects on my cognition where basically Oxiracetam and CDP-Choline (Citicoline) both on their own and in conjunction. I tried a lot of other supps and drugs but those are the best so far.
(-they both seem to have dopamineric methods of action which I enjoy. I'm sure for the CDP-Choline, but I'll need to do some research on the Oxiracetam later)

Good effects on getting stuff done or working on a tight shedule are Modafinil and Adrafinil. I sucessfully wrote my bachelor thesis in a few weeks on the influence of them. Ritalin worked well for that too, but I do not have a script and I have good access to the previous mentioned.

Thats ok, not overwhelming but still helpful:
Piracetam, Ani, Pram, ALCAR, DLPA, NALT, Tyrosine, Caffeine, Choline, l-theanine, Bacopa, Rhodiola Rosea



What did not work for me was (and what I think are dangerous without a medical condition)

Donepezil, Phenibut, DMAA, Ephedrin, PEA, Fluoxetine, Pregnenolone


Sulbutiamine (not sure about this, will give it another try sometime)





Conclusion:
Check that your diet is in check and that you do some weight lifting and cardio at least twice a week.
Then start with the beloved basics:

Piracetam, Fish Oil, Multi Vit., Choline Source

if this does not give you the effects you are looking for either replace Piracetam by Oxiracetam or pick CDP as your choline source.

If you do not get any benefit from either Oxi nor Pir, you might try a fat soluble racetam such as Aniracetam.

If motivation/ energy levels are an issue, you may want to boost your catecholamine levels by picking a precusor such as l-tyrosine, NALT, Phenylalanine or DLPA. You may also add vitamin b6 as a coenzyme for the convertion from the precusor to dopamine. Preferable in the form of p5p.
Supplementation of additional vitamin C can aid the convertion of dopamine to noradrenaline.

If all this does not help you I would use one of the "blockbusters" such as

Methylphenidat
Modafinil
Adrafinil

Though as explained, I do not think that those available substances cover all aspects of "cognitive enhancement". There are actually studies that show this substances may impair cognition in healthy, intelligent individuals.

My perfect cognitive enhancer so far is Oxiracetam closely followed by CDP-Choline.

[jalarcon]

Ginkgo helps with brain function

[Tone]

i notice theres a huge ratio of cognitive to feel-good demand

in other words theres tons and tons of threads about what causes cognitive enhancement compared to much less about what causes well-being. I find this very strange. And yes i know, this is the cognitive enhancer category of the forum.

[Flex]

I am working on a book that addresses this as we speak You know I share many of your same thoughts Tone.

[Jakare]

i notice theres a huge ratio of cognitive to feel-good demand

in other words theres tons and tons of threads about what causes cognitive enhancement compared to much less about what causes well-being. I find this very strange. And yes i know, this is the cognitive enhancer category of the forum.

Curcumin causes well-being and at the same time some cognitive enhancement. Pretty amazing.

[Yoder]

[quote name='Tone' date='Oct 24, 2011, 08:28 PM' post='116693']
i notice theres a huge ratio of cognitive to feel-good demand

[/quote


True.. I can always concentrate more when I feel great!

[Yoder]

i notice theres a huge ratio of cognitive to feel-good demand

in other words theres tons and tons of threads about what causes cognitive enhancement compared to much less about what causes well-being. I find this very strange. And yes i know, this is the cognitive enhancer category of the forum.

Curcumin causes well-being and at the same time some cognitive enhancement. Pretty amacing.

Curcumin's the ingredient in Turmeric, right? That's next on my list to try...

[Flex]

Curcumin (tumeric) is a wonderful compound. Lots of research going on right now for preventing Alzheimer's. The only down side is the BO lol.

[Jakare]

Curcumin (tumeric) is a wonderful compound. Lots of research going on right now for preventing Alzheimer's. The only down side is the BO lol.

BO? What does it mean? Please...
I was wondering why I felt happier while taking Curcumin until I found it is suppose to be excellent to rise serotonin (among dopamine).
http://emediahealth.com/2011/07/02/curcumi...ical-disorders/
http://www.ncbi.nlm.nih.gov/pubmed/19000708

[Flex]

Body odor BTW if you have never had it, fresh turmeric is awesome! Looks just like ginger, but is incredibly pungent. Great on salmon.

[Jakare]

No out of normal body odor fortunately

[Tone]

unless you have a dementia spectrum disease of the brain, the most enhancing substance to cognition and intellect performance is one that causes an increase in energy and well-being.

In other words example: Sigmund Freud was a coke addict and had nootrpics existed at the time and he taken them instead, he would have gotten very little or no enhancement in his writings compared to the notorious and dangerous drug he did use.

So for cognitive enhancement we must have energy & wellbeing based drugs that are nontoxic and come with another drug or technology that prevents tolerance & dependence.

Many people take a regimen of nootropics and give them 5 star reviews from the places they ordered from because they are excited about them and "into" them like a hobby even if in reality they are a 1 star or 1½ stars on a reasonably calibrated scale of 1 to 5, and even less if you raise expectations and idealism more.

This is the reason why Flex would answer "Dexedrine" first. Flex is serious and dislikes placebos or weak results.

[the_newsoul]

A derivate of curcumin, ASC-J9, is being studied to treat baldness and cancer. Looks like curcumin has many many benefitial effects.