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> Discovery opens up new line of attack against viruses, Potentially VERY important findings wrt treatments
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post Nov 05, 2010, 06:05 PM
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Immune discovery opens up new line of attack against viruses

The immune system has been found to target viruses inside cells, suggesting new strategies against infections including the common cold and winter vomiting bug


In a series of experiments, Dr Leo James at the Laboratory for Molecular Biology in Cambridge found that in many cases, antibodies do very little to stop viruses from infecting cells. Instead, the antibodies cling to the viruses when they invade cells and use the cells' own biological machinery to kill the virus.

James showed that once inside an infected cell, antibodies attract a protein called TRIM21. This in turn signals to the cell's equivalent of a waste disposal machine, a large cluster of proteins called a proteasome. When the proteasome arrives, it latches on to TRIM21 and goes to work, dismantling the virus piece by piece. The process happens quickly, and often before the virus has a chance to cause harm.

http://www.guardian.co.uk/science/2010/nov...system-antibody
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