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> Benfotiamine and alzheimer
Jakare
post Jul 04, 2010, 04:05 PM
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Just find this study at pubmed:
http://www.ncbi.nlm.nih.gov/pubmed/20385653
Brain. 2010 May;133(Pt 5):1342-51. Epub 2010 Apr 12.

Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, Sun X, Zhao L, Yu M, Xu Z, Dong W, Qin Y, Fei G, Zhong C, Xu TL.

Department of Neurology, Zhongshan Hospital & Shanghai Medical College, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China.

Abstract
Reduction of glucose metabolism in brain is one of the main features of Alzheimer's disease. Thiamine (vitamin B1)-dependent processes are critical in glucose metabolism and have been found to be impaired in brains from patients with Alzheimer's disease. However, thiamine treatment exerts little beneficial effect in these patients. Here, we tested the effect of benfotiamine, a thiamine derivative with better bioavailability than thiamine, on cognitive impairment and pathology alterations in a mouse model of Alzheimer's disease, the amyloid precursor protein/presenilin-1 transgenic mouse. We show that after a chronic 8 week treatment, benfotiamine dose-dependently enhanced the spatial memory of amyloid precursor protein/presenilin-1 mice in the Morris water maze test. Furthermore, benfotiamine effectively reduced both amyloid plaque numbers and phosphorylated tau levels in cortical areas of the transgenic mice brains. Unexpectedly, these effects were not mimicked by another lipophilic thiamine derivative, fursultiamine, although both benfotiamine and fursultiamine were effective in increasing the levels of free thiamine in the brain. Most notably, benfotiamine, but not fursultiamine, significantly elevated the phosphorylation level of glycogen synthase kinase-3alpha and -3beta, and reduced their enzymatic activities in the amyloid precursor protein/presenilin-1 transgenic brain. Therefore, in the animal Alzheimer's disease model, benfotiamine appears to improve the cognitive function and reduce amyloid deposition via thiamine-independent mechanisms, which are likely to include the suppression of glycogen synthase kinase-3 activities. These results suggest that, unlike many other thiamine-related drugs, benfotiamine may be beneficial for clinical Alzheimer's disease treatment.

I know about the last new in regards to benfotiamine and cancer, which to be honest dont convence me yet, but i wonder if having a family history of alzheimer will make the light risk of cancer assumable, without mention to the anti glycation properties.
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GodConsciousness
post Jul 05, 2010, 07:13 AM
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Interesting study Jakare.
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Jakare
post Jul 05, 2010, 07:45 AM
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QUOTE(GodConsciousness @ Jul 05, 2010, 05:13 PM) *

Interesting study Jakare.

Im currently taking subultiamine maybe every two weeks just to replenish brain levels, what doesnt seems to be very usefull being subultiamine water-soluble it wont last longer in brain ¿what about its effects? Benfotiamine instead its fat-soluble it means it will remain inside cells longer, doesnt it?
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GodConsciousness
post Jul 05, 2010, 08:15 AM
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You may well be right Jakare. I would like to see some further studies on this and let us know if you come across any. However, Sulbutiamine does effectively transport thiamine across the blood-brain barrier.
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Anne`s fine
post Nov 26, 2012, 09:21 PM
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Suzhou vosun chemical Co.,Ltd specialises in products to improve memory, mental performance, attention span, and brain function. We are supplying new products to improve mental performance and slow brain aging.Hope it may help you.
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