Neuron regeneration..., Is it possible or are people just not trying any more? Options

[dutch84]

Can it be done?

[lucid_dream]

you know that some neurons are generated throughout adult life. Is this what you're talking about?

[dutch84]

No. I mean artificially.

Like therapeutically.

[maximus242]

You mean causing neurons to regenerate at an abnormal rate through artificial substances such as nootropics?

[kortikal]

nerve growth factors would cause neurons to grow.

You could also use fetal neural implants

[Kclo4x]

nerve growth factors would cause neurons to grow.

You could also use fetal neural implants

Nerve growth factor (NGF) is a factor vital for the growth and functional maintenance of nerve tissue. The authors found that a rosemary (Rosmarinus officinalis L.) extract enhanced the production of NGF in T98G human glioblastoma cells. Furthermore, the results indicated that carnosic acid and carnosol, which are major components of the rosemary extract, were able to promote markedly enhanced synthesis of NGF.

PMID: 14600414

according to the this wonderful forum: http://www.imminst.org/forum/index.php?showtopic=14473&hl=

[dutch84]

I guess my main interest is in healing the schizophrenic brain.

[simon]

ARTICLES
The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells
C Richter-Landsberg and B Jastorff
Nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma PC12 cells has been described to be synergistically potentiated by the simultaneous addition of dibutyryl cAMP. To elucidate further the role of cAMP in NGF-induced neurite outgrowth we have used the adenylate cyclase activator forskolin, cAMP, and a set of chemically modified cAMP analogues, including the adenosine cyclic 3',5'-phosphorothioates (cAMPS) (Rp)-cAMPS and (Sp)-cAMPS. These diastereomers have differential effects on the activation of cAMP- dependent protein kinases, i.e., (Sp)-cAMPS behaves as a cAMP agonist and (Rp)-cAMPS behaves as a cAMP antagonist. Our data show that the establishment of a neuritic network, as observed from PC12 cells treated with NGF alone, could not be induced by either forskolin, cAMP, or cAMP analogues alone. The presence of NGF in combination with forskolin or cAMP or its agonistic analogues potentiated the initiation of neurite outgrowth from PC12 cells. The (Sp)-cAMPS-induced stimulation of NGF-mediated process formation was successfully blocked by the (Rp)-cAMPS diastereomer. On the other hand, NGF-stimulated neurite outgrowth was not inhibited by the presence of the cAMP antagonist (Rp)-cAMPS. We conclude that the morphological differentiation of PC12 cells stimulated by NGF does not require cAMP as a second messenger. The constant increase of intracellular cAMP, caused by either forskolin or cAMP and the analogues, in combination with NGF, not only rapidly stimulated early neurite outgrowth but also exerted a maintaining effect on the neuronal network established by NGF. "

[simon]

The Anti-Dementia effect of Lion's Mane mushroom and its clinical application - Hericium erinaceum - Lion's Mane

http://findarticles.com/p/articles/mi_m0IS..._114820665/pg_2

[simon]

Supplements possibly in the running for NGF

Alpha GPC
Hydergine
Idebonone
Ashwagandha
Nicergoline
Huperzine
Deprenyl
Royal jelly
Pregnenolone