Hallucinogens, mechanism of action, Difference between 2A agonists and 2A agonists that are hallucinogens Options

[Orbz]

Gonzalez-Maeso et al (2007)
Hallucinogens recruit specific cortical 5-HT2A receptor-mediated signaling pathways to affect behavior
Neuron 53;3, 439-452

The study looked at 5-HT2A agonists which are hallucinogens and 5-HT2A agonists which are not. The difference is in the down stream signalling.

While lisuride and LSD both act at 2AR expressed by cortex neurons to regulate phospholipase C, LSD responses also involve pertussis toxin-sensitive heterotrimeric Gi/o proteins and Src. These studies identify the long-elusive neural and signaling mechanisms responsible for the unique effects of hallucinogens.

Might this also be the difference betwen atypical and typical antipsychotics causing neurloeptic malignant syndrome? Typical antipsychotics induce second messengers through D2 receptors which atypicals don't?