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> Are there antiaging compounds and do they work?, HGH, others?
xanadu
post Jun 24, 2007, 12:58 PM
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There are a variety of substances that claim to have antiaging properties. We all want to live longer and be healthier so when claims like this are made about anything, it draws our interest. Human growth hormone (HGH) is one of the substances touted as having age slowing effects. The effectiveness of this hormone is not perfectly clear.

http://www.mayoclinic.com/health/growth-hormone/HA00030

growth hormone (HGH): Does it slow aging process?
If you're willing to pay thousands, some doctors promise to reverse the signs of aging with human growth hormone (HGH). Before you sign up, get the facts.

Your body naturally makes growth hormone to help fuel growth during your childhood and to help maintain your tissues and organs throughout your life. Beginning in your 40s, your pituitary gland — the pea-sized structure at the base of your brain where growth hormone is made — slowly reduces the amount of the hormone it produces.

Some people believe the dwindling level of growth hormone is responsible for the frailty that typically comes with getting older. And that's prompted some who are concerned about growing old and losing independence to turn to injections of synthetic human growth hormone (HGH) to stave off the realities of old age. But there's little evidence to suggest human growth hormone is the Fountain of Youth.
Who needs to take human growth hormone?

Synthetic human growth hormone is available only by prescription and is administered through an intramuscular injection. It's currently approved to treat adults with true growth hormone deficiency — not the expected decline in growth hormone due to aging. Growth hormone deficiency can be caused by pituitary tumors and radiation or surgery to the pituitary gland, among other causes.

Human growth hormone is also approved for:

* Children with short stature
* Children with kidney failure
* Children with Prader-Willi syndrome
* Children with Turner's syndrome
* Muscle wasting associated with AIDS and HIV

Studies of adults with growth hormone deficiencies show that injections of human growth hormone can:

* Increase bone density
* Increase muscle mass
* Decrease body fat
* Bolster the heart's ability to contract
* Improve mood and motivation
* Increase exercise capacity

Because of those results, some people believe that synthetic human growth hormone can help healthy older adults who have naturally low levels of growth hormone regain some of their youth and vitality.
What can human growth hormone do for healthy older adults who don't need it?

Studies of healthy older adults taking human growth hormone are limited. Many involve a small number of people followed for a short period of time. The studies that have been conducted have found that human growth hormone injections can increase muscle mass and reduce the amount of body fat in healthy older adults.

That increase in muscle doesn't translate into increased strength. Though the study participants gained muscle, they weren't any stronger. One study compared older men who took human growth hormone with older men who went through strength training programs. The bottom line: Strength training can increase both your muscle mass and your strength, making it cheaper and more effective than taking human growth hormone.

It isn't clear whether human growth hormone can provide other benefits, such as increased bone density and improved mood, to healthy adults. Most of the research into human growth hormone has focused on people with true growth hormone deficiencies.
Are there any risks to taking human growth hormone if you don't need it?

Taking human growth hormone can cause a number of side effects, including:

* Swelling in your arms and legs
* Arthritis-like symptoms
* Carpal tunnel symptoms
* Headaches
* Bloating
* Muscle pain
* Diabetes
* Abnormal growth of bones and internal organs
* Hardening of the arteries
* High blood pressure

Some evidence shows that side effects of human growth hormone treatments may be more likely in older adults than in younger adults. Also, because the studies of healthy adults taking human growth hormone have been short term, it isn't clear whether these side effects could eventually dissipate or become worse. For instance, though human growth hormone produced arthritis-like symptoms, it isn't clear if this would progress into arthritis. More study is needed.
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xanadu
post Jun 25, 2007, 12:31 PM
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You could say that any compound that gives health benefits is an antiaging substance. "Aging" seems to imply the degenerative effects of time. So in that sense vitamins and anything good for you is anti aging. Here is one that has been around for a long time and gotten researched.

http://www.ceri.com/deprenyl.htm

Deprenyl: A Universal
Anti-Aging Strategy?

by Ward Dean, M.D., and Steven Wm. Fowkes

The precipitous declindopamine-containing neurons in the human brain after age 45 e of is a universal characteristic of the aging process. The nigrostriatal region of the brain is richest in dopamine and undergoes the most rapid aging of any brain area. People who’s brain nigrostriatal regions age prematurely develop symptoms of Parkinson’s disease, formerly called the shaking palsy. Age-associated depletion of dopamine also accounts for less noticeable symptoms, like decline in drives, most notably male sex drive.
Unique Pharmacology of Deprenyl

Deprenyl (selegiline) provides selective protection against the age-related degeneration of the dopaminergic nervous system. It protects sensitive dopamine-containing neurons from the age-associated increases in glial cells (non-neuron brain cells) and the monoamine oxidase (type cool.gif that they contain. Deprenyl is the first selective inhibitor of MAO-B ever discovered, it is the only one used in clinical practice, and it remains the scientific reference standard for B-type inhibition after more than 40 years.

Deprenyl also competitively inhibits the uptake of dopamine, norepinephrine and epinephrine (collectively referred to as catecholamines) into neurons. This unique ability among the MAO inhibitors prevents the “cheese effect,” a dangerous hypertensive reaction caused by neural uptake of tyramine from tyramine-containing foods like aged cheeses, certain wines, yeast, beans, chicken liver and herring. Deprenyl exhibits no significant cheese effect at therapeutic dosages, and only minimal effects at extremely high dosages.
Variable Aging in the Brain

The rate at which dopamine neurons age is apparently quite variable. Prior to age 45, dopamine levels remain fairly stable. Starting at age 45, average dopamine content in healthy individuals decreases linearly 13% per decade (see illustration 1). When it reaches approximately 30%, Parkinson symptoms result (gray area). Below 10%, death results. Although the average decrease in dopamine is 13% per decade, some individuals exhibit more rapid decline and others less rapid decline. People experiencing rapid dopamine decline manifest with Parkinson’s disease. Those with normal or slow decline (see illustration) die before Parkinson symptoms become apparent.

This model of nigrostriatal aging and the development of Parkinson’s disease has been advanced by Dr. Jozsef Knoll, the world’s most prominent deprenyl researcher. He suggests that Parkinsonism may be a generic condition of the human species that does not currently manifest in very many people because of our limited average lifespan. He also suggests a general strategy of long-term deprenyl use for the prevention of nigrostriatal aging in the above-45-year-old population.
Deprenyl and Antioxidant Defenses

The sensitivity of the dopaminergic nervous system to oxidizing free radicals is well established. Oxidative polymerization of aromatic amino acids (e.g., phenylalanine, tyrosine, dopa, tryptophan) and aromatic monoamine neurotransmitters (e.g., norepinephrine, epinephrine, dopamine and serotonin) lead to the formation of melanin, a black pigment which is a characterizing feature of the nigrostriatal (black-striped) neurons. Chronic deprenyl treatment lessens the rate of melanin production.

Two oxidized derivatives of dopa and dopamine (6-hydroxydopa and 6-hydroxydopamine, respectively) are potent neurotoxins. The protective effect of deprenyl in lessening the neurotoxic effect of these two chemicals appears to correlate with increased antioxidant enzyme levels, superoxide dismutase (SOD) [Knoll, 1989] and catalase [Carrillo, 1991]. The increase in antioxidant enzymes is proportional to the amount of deprenyl given. The protective influence of deprenyl is selective for dopaminergic neurons; increased SOD is not noted throughout the rest of the brain.
Life Extension and Cognitive Enhancement

Although the long-term use of deprenyl in normal people as a life-extension and cognitive-enhancing drug has yet to be definitively studied, animal research is extensive. Age-associated decrease in sexual performance and hunger drive in rodents (a dopaminergic function) is dramatically inhibited.

The lifespan studies of deprenyl in rodents is equally dramatic (see illustration 2); all of the control rats die before the first deprenyl-treated rat dies.



The life-extending influence of deprenyl is not mediated through a food-restriction mechanism. Deprenyl-treated animals maintain body weight better than control animals.

Early research with deprenyl in humans (early diagnosed Parkinson patients) shows delayed development of symptoms and delayed need for L-dopa therapy. In combination with other drugs, deprenyl has significantly prolonged the survival of Parkinson patients.
Conclusion

Deprenyl’s low level of toxicity, few side-effects, and unique spectrum of pharmacological activities make it ideal for prophylaxis against nigrostriatal aging and the secondary aging symptoms accompanying the decline of the dopaminergic nervous system. Deprenyl is a drug of choice for Parkinson’s disease and is currently being established as a treatment for Alzheimer’s disease. Eventually, deprenyl may become recognized as a general treatment for aging in the above-45-year-old population.
References:

Knoll J, (–)Deprenyl-medication: A strategy to modulate the age-related decline of the striatal dopaminergic system. J Am Geriatr Soc 40(8): 839-47, August 1992.

Knoll J, The pharmacology of selegiline ((–)deprenyl). New aspects. Acta Neurol Scand 126: 83-91, 1989.

Carillo MC, Kanai S, Nohubo M, et al., (–)Deprenyl induced activities of both superoxide dismutase and catalase in young male rats. Life Sci 48: 517, 1991.

Knoll J, The possible mechanism of action of (–)deprenyl in Parkinson’s disease. Journal of Neural Transmission 43: 239-44, 1978.

Knoll J, Yen TT and Dallo J, Long-lasting, true aphrodisiac effect of (–)deprenyl in sluggish old male rats. Mod Probl Pharmacopsychiat 19: 135-53, 1983.

Sunderland T et al., Tyramine pressor sensitivity changes during deprenyl treatment. Psychopharmacology 1985.

Tariot PN et al., L-Deprenyl in Alzheimer’s Disease: Preliminary evidence for behavioral change with monoamine oxidase B inhibition. Archives of General Psychiatry 44: 427-33, May 1987.

Martini E et al., Pharmacopsychiatry 20: 256, 1987.

Knoll J, The striatal dopamine dependency of life span in male rats. Longevity study with (–)deprenyl. Mechanisms of Ageing and Development 46: 237-62, 1988.

Knoll J, Extension of life span of rats by long-term (-)deprenyl treatment. Mount Sinai J Med 55: 67-74, 1988.

The Parkinson Study Group, Effect of deprenyl on the progression of disability in early Parkinson’s disease. The New England Journal of Medicine 321: 1364-71, 16 November 1989.

Letters to the Editor on deprenyl in Parkinson’s disease, The New England Journal of Medicine 322: 1526-7, 24 May 1990.

Milgram NW et al.
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alisha99
post Jul 26, 2012, 01:00 AM
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Anti aging supplements work without no or few side effects.
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Flex
post Jul 26, 2012, 12:17 PM
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QUOTE(alisha99 @ Jul 26, 2012, 02:00 AM) *

Anti aging supplements work without no or few side effects.


False claim. What supplements? If you are referring to deprenyl, there are most certainly very serious potential side effects. The fact is no one really knows what any of these "anti aging" supplements do because there has not been enough time to test them. Just look how horrible the side effects hormone replacement therapies have proven to be for women--a 50% increase in breast cancer risk if I do recall.
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KoolK3n
post Jul 26, 2012, 06:41 PM
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QUOTE(Flex @ Jul 26, 2012, 03:17 PM) *

QUOTE(alisha99 @ Jul 26, 2012, 02:00 AM) *

Anti aging supplements work without no or few side effects.


False claim. What supplements? If you are referring to deprenyl, there are most certainly very serious potential side effects. The fact is no one really knows what any of these "anti aging" supplements do because there has not been enough time to test them. Just look how horrible the side effects hormone replacement therapies have proven to be for women--a 50% increase in breast cancer risk if I do recall.


If you looked at his previous posts, its obvious the account is fake.
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Flex
post Jul 27, 2012, 09:52 AM
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QUOTE(KoolK3n @ Jul 26, 2012, 07:41 PM) *

QUOTE(Flex @ Jul 26, 2012, 03:17 PM) *

QUOTE(alisha99 @ Jul 26, 2012, 02:00 AM) *

Anti aging supplements work without no or few side effects.


False claim. What supplements? If you are referring to deprenyl, there are most certainly very serious potential side effects. The fact is no one really knows what any of these "anti aging" supplements do because there has not been enough time to test them. Just look how horrible the side effects hormone replacement therapies have proven to be for women--a 50% increase in breast cancer risk if I do recall.


If you looked at his previous posts, its obvious the account is fake.


Lots of fake posts going around. Moderators need to do some cleaning. I even see that when I am gone for a month, Dr. Lee Crost fake M.D. returns to the scene...
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KoolK3n
post Jul 30, 2012, 11:18 PM
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QUOTE(Flex @ Jul 27, 2012, 12:52 PM) *

QUOTE(KoolK3n @ Jul 26, 2012, 07:41 PM) *

QUOTE(Flex @ Jul 26, 2012, 03:17 PM) *

QUOTE(alisha99 @ Jul 26, 2012, 02:00 AM) *

Anti aging supplements work without no or few side effects.


False claim. What supplements? If you are referring to deprenyl, there are most certainly very serious potential side effects. The fact is no one really knows what any of these "anti aging" supplements do because there has not been enough time to test them. Just look how horrible the side effects hormone replacement therapies have proven to be for women--a 50% increase in breast cancer risk if I do recall.


If you looked at his previous posts, its obvious the account is fake.


Lots of fake posts going around. Moderators need to do some cleaning. I even see that when I am gone for a month, Dr. Lee Crost fake M.D. returns to the scene...


I think the whole website needs modification.
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