Antipsychotic rebound Options

[Tone]

take an antipsychotic and cause dopamine and 5-HT2a blockade. Meanwhile your receptors are upregulating. then when the antipsychotic finally wears off, the rebound / single dose withdrawal is a slight high from having upregulated D2 and 5HT-2a receptors.

[Hey Hey]

take an antipsychotic and cause dopamine and 5-HT2a blockade. Meanwhile your receptors are upregulating. then when the antipsychotic finally wears off, the rebound / single dose withdrawal is a slight high from having upregulated D2 and 5HT-2a receptors.

Gosh, you have a lot to learn about antipsychotics and receptors, for example (many others):

Traditional antipsychotic drugs are blockers (antagonists) of dopamine receptors D2 or D3.

Blockage of D2 receptors is correlated with clinical effectiveness of most (not all) antipsychotic agents.

Cocaine and amphetamine, dopamine agonists, can precipitate or aggravate schizophrenia-like symptoms.

Clozapine is a blocker of the D4 receptor.

(Risperidone is a blocker of both D2 and 5-HT2 receptors.)

There is an increased amount of D3 receptors in the brains of deceased, nondrug-treated schizophrenics as compared to similar drug-treated schizophrenics.

AND THE EFFECTS YOU MENTION ARE NOT NECESSARILY GOING TO HAPPEN AFTER ONE DOSE, BUT MIGHT REQUIRE MANY DOSES.

AND YOU MENTION NON OF THE POTENTIAL SIDE-EFFECTS OF TAKING ANTIPSYCHOTICS, SOME OF WHICH ARE SERIOUS (EG AGRANULOCYTOSIS) AND ONE OF WHICH CAN BE DEATH!!!!!

BEWARE OF THE PREVIOUS POST ANY READERS

(From, amongst other things, a qualified medicinal chemist)

[Neural]

thanks for the clarification Hey Hey