Stablon is a smart drug Options

[Tone]

trust me, youll feel a lot more focused and improved from taking stablon than any of the other smart drugs like paracetam or huperzine. stablon has a huge effect on neuroplasticity. stablon makes your brain process information faster and easier. its a real head clearer with no side effects. it feels good to lower excess serotonin, excess serotonin is so inhibitory, so stuplifying, makes you feel all weird, gets in the way. you know, MDMA doesnt owe its great effects just to serotonin release.. it actually lowers serotonin activity in the limbic system. Raised Serotonin being good is a myth, thats why people take SSRIs and feel like shit.

research stablon if youd like

http://www.tianeptine.com/
http://www.stablon.com/

[dutch84]

How does it effect schizophrenics?

[kLee]

How does it effect schizophrenics?

Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications.
Jezova D.

Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia. ueenjezo@savba.sk

The involvement of excitatory amino acids in the control of ACTH release is well established. Activation of ionotropic glutamate receptors has a stimulatory effect on ACTH release, while the role of metabotropic receptors is not yet understood in detail. Glutamatergic regulation of ACTH release has a clear significance for the stress response and neuroendocrine functions during development. A dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis has been reported in several psychiatric and neurological disorders. So far, only fractional indices on the clinical importance of the interaction between glutamate and ACTH secretion have been obtained in both preclinical and clinical studies. Some antidepressant drugs, such as tianeptine, which were found to modulate ACTH release, appear to interfere with brain glutamatergic system. Changes in ACTH and cortisol release may be of importance for mood stabilizing effects of antiepileptic drugs modulating glutamate release, such as lamotrigine. Brain glutamate and HPA axis interaction seems to be of importance in alcohol and drug abuse. Little information is available on ACTH release in response to glutamate-modulating drugs used in the treatment of schizophrenia and Alzheimer disease. Nevertheless, pharmacological interventions influencing interaction between glutamate and the HPA axis are promising treatment possibilities in psychiatry and neurology.

PMID: 16388118



Plasticity at hippocampal to prefrontal cortex synapses is impaired by loss of dopamine and stress: importance for psychiatric diseases.
Jay TM, Rocher C, Hotte M, Naudon L, Gurden H, Spedding M.

INSERM E 0117, Physiopathologie des Maladies Psychiatriques, Centre Paul Broca, 2ter rue d'Alesia, 75014 Paris, France. jay@broca.inserm.fr

The direct hippocampal to prefrontal cortex pathway and its changes in synaptic plasticity is a useful framework for investigating the functional operations of hippocampal-prefrontal cortex communication in cognitive functions. Synapses on this pathway are modifiable and synaptic strength can be turned up or down depending on specific patterns of activity in the pathway. The objective of this review will be to summarize the different studies carried out on this topic including very recent data and to underline the importance of animal models for the development of new and effective medications in psychiatric diseases. We have shown that long-term potentiation (LTP) of hippocampal-prefrontal synapses is driven by the level of mesocortical dopaminergic (DA) activity and more recently that stress is also an environmental determinant of LTP at these cortical synapses. Stimulation of the ventral tegmental area at a frequency known to evoke DA overflow in the prefrontal cortex produces a long-lasting enhancement of the magnitude of hippocampal-prefrontal cortex LTP whereas a depletion of cortical DA levels generates a dramatic decrease in this LTP. Moreover, hippocampal stimulation induces a transient but significant increase in DA release in the prefrontal cortex and an optimal level of D1 receptor activation is essential for LTP expression. We recently investigated the impact of stress on hippocampal-prefrontal LTP and demonstrated that exposure to an acute stress causes a remarkable and long-lasting inhibition of LTP. Furthermore, we demonstrated that tianeptine, an antidepressant which has a unique mode of action, and clozapine an atypical antipsychotic when administered at doses normally used in human testing are able to reverse the impairment in LTP. Stressful life events have a substantial causal association with psychiatric disorders like schizophrenia and depression and recent imaging studies have shown an important role of the limbic-cortical circuit in the pathophysiology of these illnesses. Therefore, we proposed that agents capable of reversing the impairment of plasticity at hippocampal to prefrontal cortex synapses have the potential of becoming new therapeutic classes of antidepressant or antipsychotic drugs.


PMID: 15325962

[dutch84]

Thanks kLee. That was very helpful.

[Lummar]

I just found this place yesterday and have recently been introduced to Stablon, though I haven't tried it yet. But it appears to be exactly what I need. I basically suffer from PTSD, as a result of an abusive parent. I truely believe there has been severe damage done to my hippocampus and hypothalamus, as a result. Over the past month I've been using CES (cranial electro-stimulation) to pretty good results. There is evidence that CES works to stimulate and heal parts of the limbic system.

Anyway, I'm really excited to add Stablon into the mix. I'm weary though of meds, but this one appears much different from your standard SSRI's. I've been on Paxil before and I don't want to go through that hell again.

Thanks for the invaluable info on Stablon and I'll let you know my progress as it comes.

-Lummar

[dutch84]

I just found this place yesterday and have recently been introduced to Stablon, though I haven't tried it yet. But it appears to be exactly what I need. I basically suffer from PTSD, as a result of an abusive parent. I truely believe there has been severe damage done to my hippocampus and hypothalamus, as a result. Over the past month I've been using CES (cranial electro-stimulation) to pretty good results. There is evidence that CES works to stimulate and heal parts of the limbic system.

Anyway, I'm really excited to add Stablon into the mix. I'm weary though of meds, but this one appears much different from your standard SSRI's. I've been on Paxil before and I don't want to go through that hell again.

Thanks for the invaluable info on Stablon and I'll let you know my progress as it comes.

-Lummar

Lummar, any progress? What happened?