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> L-Huperzine A, Acetylcholinesterase inhibitor
cerebral
post Mar 05, 2006, 09:22 PM
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Anyone have experience with Huperzine A?

According to uniquenutrition.net:
L-Huperzine A is a natural plant alkaloid (extracted from Huperzia serrata), which quickly and potently boosts memory, learning, and concentration. Used worldwide for decades in adults and high school students. Is considered the most potent short term memory enhancer available.

What's the best place to buy this?



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Underman
post Mar 05, 2010, 12:16 PM
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ACHe is there for a reason. Inhibiting ACHe long term will basically give you mild brain damage, roughly equatable with excitotoxicity of high glutamate/NMDA doses, seratonin syndrome (or any toxic accumulation of molecules as a byproduct of inhibited metabolism). Also I'm not sure how much I trust the OP's study: roughly "Huperzine A also protects from damage by the experimental neuro toxin NMDA." Ok, NMDA isn't an "experimental neurotoxin". It's a receptor that you can't function without, and an amino acid that mimics glutamate (and can therefore be excitoxic just like glutamate can).

Huperzine A is an NMDA antagonist. You know what else is? Ethanol. Chronic administration of ethanol causes brain damage through precisely this pathway (not the only one however). So yes, it protects from excitoxicity, which you will pretty much only have if you have a stroke or a seizure, but it does this by inhibiting glutamate-affected signalling, which plays a major role in brain plasticity, learning and memory. The brain upregulates NMDA receptors in response to its antagonism, but this is not a good thing. Huperzine A will, over time, increase NMDA desensitization and kill your ability to learn information.

It is also a potassium antagonist. You know what else is? Lamictal, and I can tell you from personal experience that chronic lamictal administration absolutely destroys your memory. Don't take my word for it, look up K+ role in synaptic transmission.

Huperzine A is most likely not safe long term. Ache inhibitors are potent neurotoxins. I believe black widow poison is ache. Serin gas is an ache inhibitor. So taking highly purified huperzine A is not the same safe medicine that the Chinese use for short term administration (in far smaller doses) in traditional medicine. I'd be very careful, and evaluate how long I want to live a healthy lifestyle. ACHe inhibitors have been on the market for a long time, and they have a side effect profile to die for.
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Alexander
post Jan 20, 2012, 06:04 PM
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QUOTE(Underman @ Mar 05, 2010, 12:16 PM) *

ACHe is there for a reason. Inhibiting ACHe long term will basically give you mild brain damage, roughly equatable with excitotoxicity of high glutamate/NMDA doses, seratonin syndrome (or any toxic accumulation of molecules as a byproduct of inhibited metabolism). Also I'm not sure how much I trust the OP's study: roughly "Huperzine A also protects from damage by the experimental neuro toxin NMDA." Ok, NMDA isn't an "experimental neurotoxin". It's a receptor that you can't function without, and an amino acid that mimics glutamate (and can therefore be excitoxic just like glutamate can).

Huperzine A is an NMDA antagonist. You know what else is? Ethanol. Chronic administration of ethanol causes brain damage through precisely this pathway (not the only one however). So yes, it protects from excitoxicity, which you will pretty much only have if you have a stroke or a seizure, but it does this by inhibiting glutamate-affected signalling, which plays a major role in brain plasticity, learning and memory. The brain upregulates NMDA receptors in response to its antagonism, but this is not a good thing. Huperzine A will, over time, increase NMDA desensitization and kill your ability to learn information.

It is also a potassium antagonist. You know what else is? Lamictal, and I can tell you from personal experience that chronic lamictal administration absolutely destroys your memory. Don't take my word for it, look up K+ role in synaptic transmission.

Huperzine A is most likely not safe long term. Ache inhibitors are potent neurotoxins. I believe black widow poison is ache. Serin gas is an ache inhibitor. So taking highly purified huperzine A is not the same safe medicine that the Chinese use for short term administration (in far smaller doses) in traditional medicine. I'd be very careful, and evaluate how long I want to live a healthy lifestyle. ACHe inhibitors have been on the market for a long time, and they have a side effect profile to die for.



Black widow venom is not an acetylcholinesterase inhibitor; it stimulates production and release of acetylcholine.
"The best-studied latrotoxin is alpha-latrotoxin, which acts presynaptically to release neurotransmitters (including acetylcholine) from sensory and motor neurons"
The reason why Huperzine A can be therapeutic is because it binds reversibly to acetylcholinesterase, as opposed to poisons such as sarin gas which inactivate them permanently.
"Sarin acts on cholinesterase by forming a covalent bond with the particular serine residue at the active site. Fluoride is the leaving group, and the resulting phosphoester is robust but biologically inactive."

When it comes to the neurotoxicity of NMDA antagonists- this has been observed in rats only (in the form of Olney's lesions). An experiment was done on primates to see if these would form, and according to "the unpublished monkey data that we know about, that of Frank Sharp, [...] there is no damage at doses up to 10mg/kg." It is purported that we do not experience the same detriments that rats face because our brain metabolism works at about half the rate of rats'.

Lastly, lamictal is a sodium antagonist, not a potassium antagonist. As far as potassium antagonists go, the only side effect reported on wikipedia was Torsades de pointes- a rare form of ventricular tachychardia.

Forgive me if this was a terribly shallow investigation- I used Wikipedia for all of my sources after all. I would like anyone to correct me if I am mistaken on any of these points. The long-term usage of Huperzine A is something very interesting and potentially useful to me, and I need to know if it is something that could do me more harm than good in the long run.

I tried to post my sources but apparently I need to make more posts before I am allowed to do that. As I said before, however, everything I just said can be found on Wikipedia.
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cerebral   L-Huperzine A   Mar 05, 2006, 09:22 PM
cerebral   Here's more info I found: Huperzine Introduct...   Mar 05, 2006, 09:28 PM
LifeMirage   [size=2]I've used and given Huperzine A to man...   Mar 05, 2006, 09:49 PM
Tone   Im not sure why but any nootropic ive tried has in...   Mar 06, 2006, 05:23 PM
cerebral   how much daily dosage is recommended for huperzine...   Mar 11, 2006, 01:41 PM
LifeMirage   Depends on what other ACh compounds you are taking...   Mar 11, 2006, 01:58 PM
cerebral   I take wheat germ, which supposedly has high phosp...   Mar 11, 2006, 02:01 PM
LifeMirage   PC is a very slow acting source of choline for A...   Mar 11, 2006, 02:07 PM
cerebral   is ALC just always pricey? I would take more but ...   Mar 11, 2006, 02:10 PM
LifeMirage   Well there are several sources out there I take a ...   Mar 11, 2006, 02:14 PM
cerebral   I ended up getting some formula containing huperzi...   Mar 11, 2006, 04:04 PM
LifeMirage   If too much is taken nausea, headaches, dizzines...   Mar 11, 2006, 04:58 PM
Pedro   i don't know if it's ok to say - i buy my ...   Apr 02, 2006, 09:44 PM
LifeMirage   Its a low dose but if it works stick with it.   Apr 02, 2006, 10:01 PM
discintilldeath   Hey Lifemirage... if i play disc golf, which is a ...   Jul 08, 2007, 06:35 PM
LifeMirage   Hey Lifemirage... if i play disc golf, which is a...   Jul 08, 2007, 06:51 PM
Underman   ACHe is there for a reason. Inhibiting ACHe long t...   Mar 05, 2010, 12:16 PM
shady   ACHe is there for a reason. Inhibiting ACHe long ...   Mar 18, 2010, 06:14 PM
thinker67   You wanted to know an inexpensive place to buy hup...   Mar 27, 2010, 01:14 AM
Alexander   ACHe is there for a reason. Inhibiting ACHe long ...   Jan 20, 2012, 06:04 PM
sambocyn   to correct several factual and logical errors... ...   Feb 18, 2012, 09:26 PM
cheekyleopard   For cheap supplements (including huperzine) i reco...   Mar 29, 2010, 12:29 AM
trevdawg   Has anyone heard of Cerebral Success? i found it w...   Jan 31, 2012, 11:27 PM
Jakare   Overall it is just a mix of well known substances ...   Feb 02, 2012, 02:16 PM
semi-retarded-individual   I'm somewhat familiar with LifeMirage's po...   Feb 25, 2012, 10:54 AM
Jakare   I'm somewhat familiar with LifeMirage's p...   Feb 25, 2012, 03:02 PM
semi-retarded-individual   I'm somewhat familiar with LifeMirage's ...   Feb 25, 2012, 03:56 PM
Jakare   In such case maybe you would like to know green ...   Feb 26, 2012, 03:35 AM
k_swift1   Originally got my 200 mcg from Cognitive Nutrition...   Jun 10, 2012, 07:54 AM
Rmorgan   Originally got my 200 mcg from Cognitive Nutritio...   Jul 01, 2012, 08:20 PM
Tone   Dead ends, I tried Memantine. Something has to be ...   Jun 10, 2012, 10:26 AM
KoolK3n   AMPA Antagonist barely exist, Stablon is obscure,...   Jun 10, 2012, 01:38 PM
LeeCrostM.D.   I'm somewhat familiar with LifeMirage's p...   Jul 02, 2012, 05:40 AM
Astralogic   I was going to buy some L-Huperzine-A and begin su...   Jul 08, 2012, 12:40 AM
Flex   Ok I challenged LM before and will challenge again...   Jul 09, 2012, 09:43 PM
xsiv1   Ok I challenged LM before and will challenge agai...   Sep 24, 2013, 07:46 AM


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