My Antiaging-Cognitive Regimen, Overall Health Enhancement Options

[LifeMirage]

My AntiAging-Cognitive Regimen

Aside from exercise & diet (and until nanotech, gene & stem therapy catch up) I believe various compounds exist today that can make a dramatic impact on our health, such as greatly reducing our risk of disease, helping to slow, maintain if not reverse some aspects of aging, and even going as far as enhancing our own physical & mental abilities. In order to keep up with the latest in bioresearch I take several compounds, which in my opinion is based on reasonable scientific studies. This list changes as new research is done daily and to keep my life more interesting. Also some dosages will vary based on what is needed depending on my day. I started a simpler version of this regimen over 15 years ago and have been blood testing regularly since.

Caution: This is my own personal regimen. I strongly recommend everyone do their own research and consulting their healthcare professional before taking anything listed below. Also this list is not complete I still have much to add.

Last Updated: 12-2008

Pharmaceutical - Nutritional

Daily/E.O.D or Weekly/Monthly*:

Glycation Breakers:

Alagebrium chloride (ALT-711) 50 mg (w/f)
N-Acetyl-L-Carnosine eye drops 4x each eye
N-Acetyl-L-Carnosine 500 mg (w/f)

Telomere Lengtheners:

Carnosine 500 mg (w/f)
TA-65 25 mg

Glycation Inhibitors:

Benfotiamine 300 mg (w/f)
Pyridoxamine 300 mg

Mitochondria Antioxidants:

Chlorophyllin 400 mg (w/f)
R-Lipoic Acid (from na-rala/rala/rmct/sr) 450 mg
R-Dihydrolipoic acid 150 mg
3-Carboxy-3-Oxopropanoic acid 300 mg

SOD Upregulators

Deprenyl 1 mg (w/f)*
Rasagiline 0.5 mg (w/f)*
Bacopa 50% 300 mg
GliSODin 100 mg
Wolfberry 20% 100 mg

Mitochondria Upregulators

N-Acetyl-L-Carnitine 1 gram
Acetyl-L-Carnitine Arginate 1 gram
Propionyl-L-Carnitine 1 gram
Idebenone 180 mg (w/f)
Mitoquinone 50 mg (w/f)
Ubiquinol 200 mg (w/f)
Ubiquinone 50 mg [water soluble]
Decylubiquinone 50 mg

Cellular Membrane Agents

PPC (PhosChol, Lipostabil) 900 mg (w/f)
Centrophenoxine 500 mg (w/f)

Nootropics:

Piracetam 2,400 mg
Aniracetam 750 mg (w/f)
Oxiracetam 800 mg
Hydergine 2.25-5 mg (w/f)
Vincamine 10 mg (w/f)
Vinpocetine 10 mg (w/f)
Oxopocetine (vinpocetine citrate) 10 mg
Pyritinol 400-800 mg
CDP-Choline (Citicoline) 500 mg
Alpha GPC 300 mg
Desmopressin (Vasopressin) 2 sprays*

Brain Nutrients:

L-Huperzine A 100 mcg (w/f)
Galantamine 4 mg (w/f)
Cytisine 750 mcg*
Japanese Pharmaceutical Grade Ginkgo Biloba extract 120 mg
L-Theanine 500-1,000 mg
Lithium (as orotate) 20 mg (w/f)
Forskolin 100 mg
Methylcobalamin 30 mg
L-Methylfolate 1.6 mg
P-5-P 100-200 mg
L-Glycine 3-5 grams (w/f)*
Ashwaganda 450 mg
Myo-Inositol 5 Grams*
Scyllo-Inositol 1 gram

Antioxidants:

Trans-Resveratrol 250 mg (w/f)
Melatonin 1 mg (w/f)*
Tocotrienols 125 mg (w/f)

Immune:

Biostim 2 Courses a Year
Imm-kine 1 Course a Year
DENTAVAX 1 Course a Year
RESPIVAX 1 Course a Year
UROSTIM 1 Course a Year
Russian Choice Immune 1 Course a Year
Shark Liver Oil 1-2 grams
Lactoferrin 2-3 grams
Monolaurin 1-2 grams
Isoprinosine 1 gram
Thymic Protein A 1 Packet

Dietary Supplements:

Ortho-Core 9 caps [even days] (w/f)
LEF Mix 9 tabs [odd days] (w/f)
Sulfur (as MSM) 1,023 mg (w/f)
TMG citrate 1-2 gram
Whey Protein 20-40 grams
EPA/DHA (from Omega 3's-Fish Oil) 2.6 grams (w/f)
Vitamin K2 15 mg (w/f)
Serrapeptase 6 tablets
Adapton 2 softgels
Polaprezinc (Zinc-Carnosine) 150 mg (w/f)
Strontium (citrate) 227 mg (w/f)
Silicon (Orthosilicic Acid) 6 mg (w/f)
L-Taurine 2 grams
Astaxanthin 4 mg
Cordyceps 1 gram
Creatine 1 gram
D-chiro-Inositol 1 gram
Creatine Ethyl Ester 1 gram

Dental/Topical:

Toothpaste:

Colgate Total: Fluoride Ion (0.14% w/v), Triclosan (0.30%).
Biotene: Lactoperoxidase (100gm), Glucose Oxidase, Lysozyme, Sodium Monofluorophosphate.
LEF Toothpaste: A blend of essential oils and H2O2

I alternate different products for best inhibitory effects.

Mouthwash:

Listerine tartar control: Essential Oil blend, zinc sulfate.
(Well studied for protecting gums and teeth)
Crest Pro-Health 0.07% cetylpyridinium chloride
(Antibacterial)
Peridex: 0.12% chlorhexidine gluconate
(Very long lasting antibacterial effects)
Biotene: Lysozyme (40mg), Lactoferrin (15mg), Glucose Oxidase (2,500 units), Lactoperoxidase (2,500 units)
Hydrogen Peroxide 3%
(Antibacterial and teeth whitener)

Body Wash:

HIBICLENS: 4% chlorhexidine gluconate
(A long lasting safe antibacterial compound)

Nutribiotic: Grapefruit seed extract

Hair:

Dr. Proctor's Hair Shampoo & Serum: 3-carboxylic acid pyridine n-oxide*
Decos*
Nizoral*
(cleans hair sebum, inhibits DHT, and kills fungus that may effect hair growth)

Skin:

Prevage (Idebenone 1%)*
Beta-Alistine (Carnosine)*
Derma Q-Gel (Ubiquinol)*
Aminocare Cream (phenylacetylglutamine, phenylacetylisoglutamine)*
(a glutamine metabolite formula)
Tretinoin (Retin A) 0.05%*
(a vitamin A analog)

Diet

Food is a dual edge sword. While the wrong diet greatly increase your risk of disease and death, the right one can extend your life and improve your overall health. In the last 100 years we have been able to identify the health benefits to certain foods as well the negative impacts of others and the best ways to prepare them.

Foods Prepared:
50-75% raw, steamed, and/or very lightly boiled.
(No microwave, no deep fried, and only rarely oven cooked)

Foods Consumed:
80%-90% Organic- vegetables, grains, fish, nuts, seeds, berries, etc.

Remaining - legumes, organic fermented & raw dairy products, turkey, chicken, and rarely organic grass fed red meat.

Methods/Foods Avoided:
GMO, pasteurized dairy/juices, tap water, hydrogenated oils, irradiated foods, cloned meats and refined flours/sugars.


This thread will be edited (irrelevant or old posts deleted) as needed to maintain a high degree of quality postings.

[maximus242]

O_O holy sh*t, you guys know your drugs hu? well I have a few questions for you life, if you would indulge me ;D. Firstly can you give a description of what some of the brain nutritions do? it is also my understanding that nootropics can have some emotional side effects, what do you about this? nootropics and other drugs seem quite intresting, I assume the learning drugs aim to improve plasticity? anyways im intrested in learning more so if you could help me out it would be much appreciated

[noos]

Hi LM, thanks for your post.
I have a question:
Hydergine 2.25-5 mg (w/f)
means with or without food? because manufacturers say take without food.
thanks

[cerebral]

take without food

[shepard]

I'm pretty sure his (w/f) means with fat.

[code buttons]

Life:
I live in the gulf coast and very close to Louisiana (as in Cajun Seafood), and my diet is a little heavy in sodium. I've always been interested in finding natural high sources of Potassium to counter-balance the high sodium intake. I know about bananas, but the high sugar and carb in them makes a little less than ideal. Any advise?

[cerebral]

use salt containing potassium chloride (mixed in with NaCl)

[LifeMirage]

Life:
I live in the gulf coast and very close to Louisiana (as in Cajun Seafood), and my diet is a little heavy in sodium. I've always been interested in finding natural high sources of Potassium to counter-balance the high sodium intake. I know about bananas, but the high sugar and carb in them makes a little less than ideal. Any advise?

Carrot juice or potassium salt.

Hi LM, thanks for your post.
I have a question:
Hydergine 2.25-5 mg (w/f)
means with or without food? because manufacturers say take without food.
thanks

I take it with food because in my case it causes mild nausea if i don't, otherwise take it on an empty stomach.

[code buttons]

Thanks for the quick response. I did forget to ask you something important: What's the proper Sodium to Potassium comsumption ratio for a healthy body assimilation?

[code buttons]

use salt containing potassium chloride (mixed in with NaCl)

Thanks for the tip, Cerebral

[Trip like I do]

Sweet...."Max Headroom"!

[code buttons]

Sweet...."Max Headroom"!

Some of us are not lucky enough to look like THE ONE, Trippy. So we have to find an avatar to hide out the physical challenges inheredited with the wrong genes. I figure I'll be beautiful enough after I get Singularized. Then I won't have any thing to hide!!!

This post has been edited by code buttons: Feb 28, 2006, 08:43 PM

[OnlyNow]

LifeMirage,
Amazing. Is this a full-time job? I assume you must take a complete daily inventory of your stock for an accurate accounting of what you have and what you're running low on. Besides the amount of time it must take to measure, regulate, purchase and research all of those supplements, it must take a substantial chunk out of your day just to ingest all of them. I try to take a multivitamin tablet daily. I have to talk myself into it, as the pill is large--which almost makes me gag. With this in mind, I wonder how you manage to get it all down? This is a serious question. I shudder to think of the cost, but if this regimen ehances the quality of your life, then I'm sure it's well worth it.

[LifeMirage]

LifeMirage,
Amazing. Is this a full-time job? I assume you must take a complete daily inventory of your stock for an accurate accounting of what you have and what you're running low on. Besides the amount of time it must take to measure, regulate, purchase and research all of those supplements, it must take a substantial chunk out of your day just to ingest all of them. I try to take a multivitamin tablet daily. I have to talk myself into it, as the pill is large--which almost makes me gag. With this in mind, I wonder how you manage to get it all down? This is a serious question. I shudder to think of the cost, but if this regimen ehances the quality of your life, then I'm sure it's well worth it.

It certainly feels like one.....yes i check and double check to insure the amounts are accurate. I take them throughout the day in both pill and powder form...a protein shake here and a water filled drink there. I do truly feel great on them and it took years to get here.

[Jeff]

What's your favorite nootropic/life extension drug, regarding actual effects, not based on long-term research?

[LifeMirage]

Piracetam/Deprenyl....but its a tough call.

Good question!!

[Guest]

it was one of these chemistry outfits like Sigma ( http://www.sigmaaldrich.com ). I forget the name but will dig it up.

[LifeMirage]

Personally I would not recommend that route.... several companies sell the trademark brand that is practically guaranteed high quality. IAS, QHI, UNI, Nubrain, Biogenesis, and more.

You really should have felt something at 50 mg or more….oh and it needs to be taken with food fyi.

[Guest]

maybe I'll give it another try. Thanks LM.

[Jeff]

I'm going to be testing N-Acetyl-L-Carnitine for a month or so (however a 750mg 120ct bottle lasts me), planning on using 1.5g daily, divided into two doses (1 before breakfast, and 1 before lunch), would this amount necessitate use of ALA or NAC? Is 1.5g even enough? I see some people use up to 8G!!!!! Good grief!

I figured I would post my own regimen (as far as supps/drugs go). Tell me what you think, if you don't mind...keep in mind that $ is going to be partly an issue from here on out.

NOW Vit-min 75+ Multi
Extra C (in form of ascorbic acid), E (in form of Dl-Alpha-Tocopherol-acetate) , B-6 (in form of pyridoxine hcl), Cal/Mag/Zinc (in forms of carbonate/oxide/gluconate) (w/f)
ZMA
Fish Oil 2g of EPA/DHA (w/f)
Piracetam 2.4-4.8g
Aniracetam 450mg-900mg (w/f)
Centrophenoxine 500mg (w/f)
Choline Bitartrate 5g
Pyritinol 400-800mg (w/f)
Vinpocetine 10mg (w/f)
Taurine 4-6g
CEE 3g
Bacopa 400mg
Wellbutrin XL 300mg
Hydergine 4.5mg
L-theanine, 300mg-600mg, if/as needed
Clonazepam, 1mg-4mg, if/as needed
Valerian Root, doses vary, if/as needed
N-Acetyl-L-Tyrosine, 800mg, if/as needed

When my centro, pyritinol, CEE, Bacopa, and N-Acetyl-L-Tyrosine run out, I'm not going to continue use. I've tried Alpha-GPC and haven't noticed any difference between that and choline bitartrate (except requiring different doses), so, I'm going to continue with choline bit. as my sole choline source. I have about 80 tablets of selegiline 5mg left, but, I'm not going to use until I finish perfecting my stack (and I'm in the Army, so, urinalysis is an issue). Also, I'm seeing an endocrinologist next week due to low test and free test levels.

My diet consists mainly of boneless skinless chicken breasts, lean red meats, Eggland's Best Eggs (vegetarian fed), almonds, natural peanut butter, skim milk, Light-N-Fit yogurt (sweetened with splenda), whey/egg protein powders, maltodextrin, natural almond granola, whole oats, long grain brown rice, 100% whole wheat spaghetti and bread, and flaxseeds on occassion. Occassionally canned tuna as well.

Goals - improve mood/alleviate depression/libido, improve focus, motivation, reduce anxiety (in forms of GAD and social), improve congitive function, and memory.

This post has been edited by Jeff: Mar 04, 2006, 06:23 AM

[lucid_dream]

I have heard about alcar and choline being a good combo, but phosphotidal choline (not as lecithin) is superior to choline bitartrate for ACh synthesis. And for alcar use the HCl kind and nothing else and make sure you take it on an empty stomach w lots of water.

No vasopressin?

[Tone]

YOu forgot to add a way to bcome undepressed so someone has enough energy and money to do all these things

Piracetam makes me feel like crap, hardcore, one of the worst drugs ever

"Deprenyl 1 mg (w/f)
Rasagiline 0.5 mg (w/f)"

why do you take both?? and how rich are you?

[LifeMirage]

Telomere Lengtheners:

Carnosine 1000 mg (w/f)

Lifemirage,

The above recommendation is remarkable. I am aware of only a single study (Shao L, Li QH, Tan Z. 2004) associating decreased telomere shortening with carnosine. How did you arrive at the dose of 1 gram?

Thanks in advance.

Based on the human research at Rush Medical Center in Chicago and LEF's dosing extrapolated from animal research. But i am slowly lowering my dose and increasing my N-Acetyl-L-Carnosine as time go by.

YOu forgot to add a way to bcome undepressed so someone has enough energy and money to do all these things

Piracetam makes me feel like crap, hardcore, one of the worst drugs ever

"Deprenyl 1 mg (w/f)
Rasagiline 0.5 mg (w/f)"

why do you take both?? and how rich are you?

I continue to take deprenyl due to the massive research regarding its effects on aging and neuroprotection. However Rasagiline would appear to be more potent and has some unique effects. So i take both at the moment. Rich enough.

[Tone]

i take low dose selegiline but not everyday

my regimen is:

Tramadol, 50 mg + extra tramadol at times
Diphenhydramine every night to be able to go to sleep
Vitamins and Minerals, Saw Palmetto, Omega 3 but not daily,
Sometimes Kratom in place of Tramadol.

Wish list of things id like to take:

A ton of stablon every day
A microgram of naltrexone per day
A lot more tramadol if it had zero tolerance and dependance

[LifeMirage]

A ton of stablon every day

Doesn't everyone.

[Hey Hey]

tresbien I suggest you search on Life Extension Foundation, Pubmed and any research cited by Rush Medical Center if you want more information on Carnosine, dosing, and telomeres.

Don't forget, you can die in auto accidents. Any drugs for that?

[LifeMirage]

Don't forget, you can die in auto accidents. Any drugs for that?

Now that you ask Hydergine is used as a drug in Europe for accident victims and can help reduce the risk of death. Aside from that buckle up.

[emolian]

Don't forget, you can die in auto accidents. Any drugs for that?

Now that you ask Hydergine is used as a drug in Europe for accident victims and can help reduce the risk of death. Aside from that buckle up.

hi, just out of interest, how much Hydergine would be a good subsistence dose to future-proof you for auto-accidents?

also, about your regime, could you tell me:
why you don't take sulbutiamine (I heard it was really good),
where you get your CDP-choline from (I just can't find bulk powdered source anywhere),
and whether Advanced Research lithium orotate is a safe alternative to the AOR product (which I assume you take but which is quite expensive).

oh yes, im curious with all your knowledge and research what you think the primary cause of aging/brain aging is. A friend suggested cell membrane degredation, and so i was thinking PhosChol would be good for that.
I've also identified methylcobalamin and theanine as seemingly fairly important for mental health (as well as I think CDP-choline).
If you have time.
Thanks.

[LifeMirage]

hi, just out of interest, how much Hydergine would be a good subsistence dose to future-proof you for auto-accidents?

Depends on your age.

also, about your regime, could you tell me:
why you don't take sulbutiamine (I heard it was really good),

Not really a very impressive cognitive compound and needs more studies in my opinion.

where you get your CDP-choline from (I just can't find bulk powdered source anywhere),
and whether Advanced Research lithium orotate is a safe alternative to the AOR product (which I assume you take but which is quite expensive).

I do not list my sources online, you may pm me for this information.

oh yes, im curious with all your knowledge and research what you think the primary cause of aging/brain aging is. A friend suggested cell membrane degredation, and so i was thinking PhosChol would be good for that. I've also identified methylcobalamin and theanine as seemingly fairly important for mental health (as well as I think CDP-choline).

That's a complicated answer covered thoroughly in my book. Centrophenoxine is one of the best compounds for maintaining healthy cell membranes.

[emolian]

That's a complicated answer covered thoroughly in my book. Centrophenoxine is one of the best compounds for maintaining healthy cell membranes.

What book is this? Can you give its name or ISBN number or something?