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> The Best Mental Medication, Options are still limited in this turn of the century
Tone
post Oct 01, 2004, 11:06 PM
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The year is 2004 and the best treatment for mental dysphoria and a whole other load of symptoms is unfortunately a controversial and dependance producing one.

Opioids are the best we have. Opioids seem to have a perfect excitatory effect on just the right dopamine in just the right areas of the brain while simultaneously having a mild and positive inhibitory effect as well. They treat mental dysphoria. They treat lack of energy. They treat anxiety, and in particular, social anxiety, which other anxiety medications totally fail to treat. they invoke a feeling of dopamine drive and motivation without the anxiety and other side effects that stimulants have. They ease almost all pain with the exception of neuropathic pain. They do no physical harm to any organ systems of the body.

So what's the problem, why are opioids demonized and why cant they be widely used from mental problems as well? Of course the political and social controversy is just a bunch of made up opinion so the only REAL problem with their use is simple: Tolerance and Dependance. Opioids best work their mental magic when there is little or no tolerance. Opioid receptors quickly tend to downregulate in the presence of an agonist thus diminishing the benefits while at the same time increasing dependance and withdrawal potential.

But there is new hope. Scientists have found ways to prevent or at least significantly lower the development of tolerance. One such discovery was when scientists found that binding of a compound called DAMGO to a small number of receptors in a group caused the whole group to become upregulated. In an animal test, rats were given morphine with a small amount of DAMGO for 7 days. on the 7th day the morphine was as effective as the first day and tolerance was absent(1). Other researchers discovered the same to be true with Naltrexone. UltraLow dose Naltrexone with an Opioid effectively hinders the devolopment of tolerance and enhances analgesia(2). As a result of these findings, a medicine containing ultralow dose Naltrexone and Oxycodone called OxyTrex is already devoloped and in trials(3).

If we could have an Opioid pill where tolerance and dependance is no longer an issue, it would undoubtedly be invaluable to the treatment of many mental problems for many people. It is a moral urgency that such medicines be developed and easily available to all.

- Tone

Refs:
(1) Unisci: Reducing Tolerance To Morphine
Could Aid Pain Therapy
http://www.opioids.com/tolerance/damgo.html
--
(2) Queen's Researchers Discover Paradox Of Pain Control; Morphine Effectiveness Restored To Between 80 And 90% Of Original Amount
http://opioids.com/tolerance/paincontrol.html
--
(3)Pain Therapeutics, INC: OXYTREXâ„¢
http://www.paintrials.com/oxytrex.html
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Unknown
post Oct 02, 2004, 09:45 AM
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what sort of opioids? Morphine?
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Tone
post Oct 03, 2004, 02:21 AM
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Well i dont like morphine as much as hydrocodone, oxycodone and tramadol. the latter are more stimulating and feel much better. morphine is more sedating
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Robert the Bruce
post Nov 10, 2004, 10:56 AM
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Chiropractors Offer Hope for Kids with ADHD
http://www.hunterdonhealthonline.org/healt...ils.cfm?id=1933
In the past decade, prescriptions for Ritalin, a stimulant medication commonly used for attention deficit hyperactivity disorder (ADHD), increased five-fold, with 90 percent of all prescriptions worldwide consumed in the United States. As many parents grow leery of the traditional medical approach to ADHD, doctors of chiropractic are offering promising results with non-drug treatments that focus on postural muscles, nutrition and lifestyle changes that affect brain activity.

Some children may simply have difficulty learning certain subjects, but the current system - in a sense - prompts school officials to encourage their parents to have the children diagnosed with ADHD, says Dr. Scott Bautch, past president of the American Chiropractic Association (ACA) Council on Occupational Health. "The higher the number of disabled kids in the school, the more funding the school can apply for," says Dr. Bautch.

Some teachers might also have difficulty with students who have a different style of learning, according to Dr. Bautch. If the child is a visual learner, and the teacher is not, perhaps the child is not being taught in a way he or she can learn. Before diagnosing the child with ADHD, Dr. Bautch recommends doctors talk to the child and the parents: "Is the child too active? Bored? Has dyslexia or a different learning pattern? It can be a behavior problem, problems at home, or frustrations with the teacher's style," explains Dr. Bautch. "If we went to a conference where the speakers taught in a way we can't learn, we would be frustrated and would misbehave - we'd get up and leave or chat to the person sitting next to us."

The traditional medical model, however, seems to follow the cookie-cutter principle. The diagnosis of ADHD is based on a questionnaire. But this is not enough, says Dr. Robert Melillo, a chiropractic neurologist. "True ADHD patients have other signs - tics, tremors, balance or postural problems, or unusual sensitivity to touch, movement, sights, or sounds." Unfortunately, although medications can keep ADHD under control, they don't cure it. Eighty percent of patients have ADHD features in adolescence, and up to 65 percent maintain them in adulthood.

Doctors of chiropractic and chiropractic neurologists offer a non-drug and non-invasive treatment alternative for ADHD patients that targets the underlying problems, not just symptoms. "Motor activity - especially development of the postural muscles - is the baseline function of brain activity. Anything affecting postural muscles will influence brain development. Musculoskeletal imbalance will create imbalance of brain activity, and one part of the brain will develop faster than the other, and that's what's happening in ADHD patients," says Dr. Melillo.

Chiropractic neurologists are trained to identify the underfunctioning part of the brain and find treatments to correct the problem, to help that hemisphere grow. "On every patient, we perform a brain function exam," says Dr. Frederick Carrick, president of the ACA Council on Neurology. "We test visual and auditory reflexes through, for example, flashing light in the eye, or asking patients to listen to music in one or the other ear."

When the problem is identified, patients are placed on a treatment program - and most of the therapies can be done at home. "Patients are asked to smell certain things several times a day ... or wear special glasses," says Dr. Mark S. Smith, a chiropractic neurologist. "We also focus on their individual problems. Some children, for example, have difficulty with planning, organization, and coordination - so they benefit from timing therapies. They learn to clap or tap to the metronome, perform spinning and balancing exercises."

Although currently no studies comparing chiropractic neurological and medical treatment for ADHD are available, chiropractic neurologists are compiling the data. "We test children before they start the treatment and then every three months," says Dr. Melillo. "Within the first three months, the children get a two-grade-level increase on average - which is pretty dramatic. With children on medications, the improvement in academic performance is short term and lasts only as long as they take the medication. Our programs change the brain function and the improvement doesn't go away."

While chiropractic neurologists have found success in treating ADHD and learning disabilities by providing the necessary brain stimulation, they also recommend nutrition and lifestyle changes that may help correct or prevent biochemical imbalances that cause ADHD.

Parents are encouraged to:

1. Remove as many food dyes, sugar, preservatives, and additives from the diet as possible.

2. Focus on natural, mostly organic foods with as few pesticides or herbicides as possible.

3. Determine if there is an allergy - usually starting with dairy and gluten and try elimination diets.

4. Stop using pesticide sprays in the house.

5. Avoid taking medications, nicotine, alcohol, and other drugs in pregnancy that may harm the fetus.

6. Find ways to relax during pregnancy. Stress on the job may affect the unborn baby's health, as well.

7. Breastfeed. The first months and years of a child's life are critical to physical and psychological development. Breastfeeding mothers' diets are important as well.

Chiropractic Care Can Help...

If you or your loved one is diagnosed with ADHD or has the symptoms, ask your doctor of chiropractic if he or she has experience treating patients with the condition. Doctors of chiropractic are trained to identify neurological problems and find individual non-invasive treatment modalities. They can also assess your nutritional status and help you find the diet that will help you manage your condition.
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Abolitionist
post Nov 28, 2004, 04:41 AM
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QUOTE (Tone @ Oct 01, 08:06 PM)
The year is 2004 and the best treatment for mental dysphoria and a whole other load of symptoms is unfortunately a controversial and dependance producing one.

Opioids are the best we have. Opioids seem to have a perfect excitatory effect on just the right dopamine in just the right areas of the brain while simultaneously having a mild and positive inhibitory effect as well. They treat mental dysphoria. They treat lack of energy. They treat anxiety, and in particular, social anxiety, which other anxiety medications totally fail to treat. they invoke a feeling of dopamine drive and motivation without the anxiety and other side effects that stimulants have. They ease almost all pain with the exception of neuropathic pain. They do no physical harm to any organ systems of the body.

So what's the problem, why are opioids demonized and why cant they be widely used from mental problems as well? Of course the political and social controversy is just a bunch of made up opinion so the only REAL problem with their use is simple: Tolerance and Dependance. Opioids best work their mental magic when there is little or no tolerance. Opioid receptors quickly tend to downregulate in the presence of an agonist thus diminishing the benefits while at the same time increasing dependance and withdrawal potential.

But there is new hope. Scientists have found ways to prevent or at least significantly lower the development of tolerance. One such discovery was when scientists found that binding of a compound called DAMGO to a small number of receptors in a group caused the whole group to become upregulated. In an animal test, rats were given morphine with a small amount of DAMGO for 7 days. on the 7th day the morphine was as effective as the first day and tolerance was absent(1). Other researchers discovered the same to be true with Naltrexone. UltraLow dose Naltrexone with an Opioid effectively hinders the devolopment of tolerance and enhances analgesia(2). As a result of these findings, a medicine containing ultralow dose Naltrexone and Oxycodone called OxyTrex is already devoloped and in trials(3).

If we could have an Opioid pill where tolerance and dependance is no longer an issue, it would undoubtedly be invaluable to the treatment of many mental problems for many people. It is a moral urgency that such medicines be developed and easily available to all.

- Tone

Refs:
(1) Unisci: Reducing Tolerance To Morphine
Could Aid Pain Therapy
http://www.opioids.com/tolerance/damgo.html
--
(2) Queen's Researchers Discover Paradox Of Pain Control; Morphine Effectiveness Restored To Between 80 And 90% Of Original Amount
http://opioids.com/tolerance/paincontrol.html
--
(3)Pain Therapeutics, INC: OXYTREXâ„¢
http://www.paintrials.com/oxytrex.html

This is nothing short of a revolutionary discovery in my mind. Controlling receptor up and down regulation may very well be a key to eliminating many disorders as well as a great deal of suffering in general.

Imagine taking a drug with the beneficial effects of mdma without the side effects that never failed to produce the desired effects.

This gives new hope for the effort to free mankind from the hedonic treadmill.

Sean
www.abolitionist-society.com
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Abolitionist
post Nov 28, 2004, 04:46 AM
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QUOTE (Robert the Bruce @ Nov 10, 07:56 AM)
Chiropractors Offer Hope for Kids with ADHD
http://www.hunterdonhealthonline.org/healt...ils.cfm?id=1933
In the past decade, prescriptions for Ritalin, a stimulant medication commonly used for attention deficit hyperactivity disorder (ADHD), increased five-fold, with 90 percent of all prescriptions worldwide consumed in the United States. As many parents grow leery of the traditional medical approach to ADHD, doctors of chiropractic are offering promising results with non-drug treatments that focus on postural muscles, nutrition and lifestyle changes that affect brain activity.

Some children may simply have difficulty learning certain subjects, but the current system - in a sense - prompts school officials to encourage their parents to have the children diagnosed with ADHD, says Dr. Scott Bautch, past president of the American Chiropractic Association (ACA) Council on Occupational Health. "The higher the number of disabled kids in the school, the more funding the school can apply for," says Dr. Bautch.

Some teachers might also have difficulty with students who have a different style of learning, according to Dr. Bautch. If the child is a visual learner, and the teacher is not, perhaps the child is not being taught in a way he or she can learn. Before diagnosing the child with ADHD, Dr. Bautch recommends doctors talk to the child and the parents: "Is the child too active? Bored? Has dyslexia or a different learning pattern? It can be a behavior problem, problems at home, or frustrations with the teacher's style," explains Dr. Bautch. "If we went to a conference where the speakers taught in a way we can't learn, we would be frustrated and would misbehave - we'd get up and leave or chat to the person sitting next to us."

The traditional medical model, however, seems to follow the cookie-cutter principle. The diagnosis of ADHD is based on a questionnaire. But this is not enough, says Dr. Robert Melillo, a chiropractic neurologist. "True ADHD patients have other signs - tics, tremors, balance or postural problems, or unusual sensitivity to touch, movement, sights, or sounds." Unfortunately, although medications can keep ADHD under control, they don't cure it. Eighty percent of patients have ADHD features in adolescence, and up to 65 percent maintain them in adulthood.

Doctors of chiropractic and chiropractic neurologists offer a non-drug and non-invasive treatment alternative for ADHD patients that targets the underlying problems, not just symptoms. "Motor activity - especially development of the postural muscles - is the baseline function of brain activity. Anything affecting postural muscles will influence brain development. Musculoskeletal imbalance will create imbalance of brain activity, and one part of the brain will develop faster than the other, and that's what's happening in ADHD patients," says Dr. Melillo.

Chiropractic neurologists are trained to identify the underfunctioning part of the brain and find treatments to correct the problem, to help that hemisphere grow. "On every patient, we perform a brain function exam," says Dr. Frederick Carrick, president of the ACA Council on Neurology. "We test visual and auditory reflexes through, for example, flashing light in the eye, or asking patients to listen to music in one or the other ear."

When the problem is identified, patients are placed on a treatment program - and most of the therapies can be done at home. "Patients are asked to smell certain things several times a day ... or wear special glasses," says Dr. Mark S. Smith, a chiropractic neurologist. "We also focus on their individual problems. Some children, for example, have difficulty with planning, organization, and coordination - so they benefit from timing therapies. They learn to clap or tap to the metronome, perform spinning and balancing exercises."

Although currently no studies comparing chiropractic neurological and medical treatment for ADHD are available, chiropractic neurologists are compiling the data. "We test children before they start the treatment and then every three months," says Dr. Melillo. "Within the first three months, the children get a two-grade-level increase on average - which is pretty dramatic. With children on medications, the improvement in academic performance is short term and lasts only as long as they take the medication. Our programs change the brain function and the improvement doesn't go away."

While chiropractic neurologists have found success in treating ADHD and learning disabilities by providing the necessary brain stimulation, they also recommend nutrition and lifestyle changes that may help correct or prevent biochemical imbalances that cause ADHD.

Parents are encouraged to:

1. Remove as many food dyes, sugar, preservatives, and additives from the diet as possible.

2. Focus on natural, mostly organic foods with as few pesticides or herbicides as possible.

3. Determine if there is an allergy - usually starting with dairy and gluten and try elimination diets.

4. Stop using pesticide sprays in the house.

5. Avoid taking medications, nicotine, alcohol, and other drugs in pregnancy that may harm the fetus.

6. Find ways to relax during pregnancy. Stress on the job may affect the unborn baby's health, as well.

7. Breastfeed. The first months and years of a child's life are critical to physical and psychological development. Breastfeeding mothers' diets are important as well.

Chiropractic Care Can Help...

If you or your loved one is diagnosed with ADHD or has the symptoms, ask your doctor of chiropractic if he or she has experience treating patients with the condition. Doctors of chiropractic are trained to identify neurological problems and find individual non-invasive treatment modalities. They can also assess your nutritional status and help you find the diet that will help you manage your condition.

Robert the Bruce,

Would you mind checking over our 'resources' page? It contains a listing of things that one can do right now to increase overall happiness and adaptability;

http://www.abolitionist-society.com/resources.htm

Please let me know if you have any suggestions for additions, edits, etc..

Thanks!!!!
Sean
www.abolitionist-society.com
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RobertBruceBaird
post Nov 28, 2004, 11:15 AM
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Dear Sean

I make no inputs here now on such things. I am following your effort with interest and I see lots of ethical problems that include such power in the hands of bureaucrats leading to a Matrix. I know of many other things that tie in with that assertion. Should you wish my inputs I request you go to another site where you can find me.
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Abolitionist
post Nov 28, 2004, 12:10 PM
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QUOTE (RobertBruceBaird @ Nov 28, 08:15 AM)
Dear Sean

I make no inputs here now on such things. I am following your effort with interest and I see lots of ethical problems that include such power in the hands of bureaucrats leading to a Matrix. I know of many other things that tie in with that assertion. Should you wish my inputs I request you go to another site where you can find me.

Ethical problems - that's an understatement - building a 'brave new world' is certainly a possibility - but something that can be avoided.

Robert, if you do have any ideas to share with me (regarding earlier post,) please PM me.

Thanks,
Sean
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Guest
post Feb 26, 2006, 09:32 PM
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I was under the impression that Naltrexone was ineffective orally. Is this product injectable?
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Tone
post Mar 04, 2006, 03:23 AM
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QUOTE(Guest @ Feb 26, 08:32 PM) *

I was under the impression that Naltrexone was ineffective orally. Is this product injectable?


You are thinking of Naloxone
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lucid_dream
post Mar 04, 2006, 03:36 AM
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Ah, hedweb. Now there's an interesting thought.
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Tone
post Jun 29, 2018, 05:24 PM
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I posted this thread in 2004 -- imagine how i feel now with the Opioid Epidemic Viral News Cycle Garbage. Which is programming people to say big pharma is horrible, lets ban opioids more !!

BUMP FOR TRUTH -- We should have deregulated Suboxone for depression -- it blocks the dysphoric ugly depressive anxiety dissociative Kappa Opioid Receptor yet partially stimulated the good, pro-social, pro-wellbeing mu receptor with an intrinsic activity that is rather low compared to full agonists, thus making it ideal in mental illness and a pain alternative for those to try first in pain. It was called Temgesic as a pain med.

Also we could have been working on a way to lower the brains mechanisms of tolerance and dependence to opioids so they could be more viable as a treatment

Even when i originally posted this, i did not believe Ultra Low Dose Naltrexone would do much of anything in tolerance and dependence, it was more of posting the concept of it, Better stuff could have been devoloped by now.

I think "blows" was still an expression used back in 2004

This authoritarianism blows, we are going down the wrong direction, the Opioid Pathways arent magically immune to innate dysfunction in all 7 billion people on Earth -- and even without being a direct treatment for a central innate dysfunction ,, they would still be more effective in people with other pathway dysfunctions !!

Its 2018 i havent found anything effective as an alternative to somehow treating the opioid pathways!! nothing works !! very high dose NSI-189 works Quite MILDLY !!

Our lifespan is still only around 80 years or so, i say we allow sick people opioids and the less-sick people can take these 4 materials that are the all-time cleanest drugs with the least side effects, cleaner than caffeine the world's most used Psychoactive:

NSI-189
Dihexa
PPAP (PhenylPropylAminoPentane)
ITPP (Inositol TrisPyroPhosphate) ( For better physical energy and endurance, very clean oxygen transport enhancer)

In my opinion these 4 drugs could be enhancement for the healthy population if they want it and allow Opioids to endogenous dysphorics and anxio people

The strong advocacy for Marijuana is a foolish tragedy because that drug is selective to healthy people getting high and any person who suffers just gets more dysphoric and anxiety attacks from it -- how clownish of a coincidence is it that the one psychoactive that is massively advocated for is that which most chronically mentally ill people get an adverse reaction to and all well people feel good on -- this is to sophisticated for people to grasp and will act as a terrible disinfo and subversion of true-health freedom because they healthy people are going to rave about it and thats the sophistication of the subversion, if you catch my concept here.

what in the hell is wrong with allowing a mentally ill person any drug they want for relief?, people act like our lifespan is 1000 years and theres some sort of protectionism that has to occur.

GODD..... DAMN IT, Im 38 now, i was 24 when i posted this

I took Tramadol with good CYP2D6 turnover to O-Desmethyl .... from 2003 to The end of 2013, i never got fully tolerant to it. It was inadequate treatment but was better off than now
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haohao
post Jun 30, 2018, 01:00 AM
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I'm not a Professor, and hope I could provide some suggestive opinions.

1. Feel sorry for the lack of mental helping methods.

2. The mental development is not just reading training or food imporvements, but needs comprehensive method with theories system. If all of you have the time and interest, you can browse my eposts here in this webforum.

3. "Experience is one way to show your interest and span for the research, which has no direct links with the innovation and best practices. In my opinion, the continuing ability-based performance with interest is the key and the related recognition is important. I thought the essence of the education was the life-long learning and improvements, in which the so-called formal and regular education should be changed into the intensive and flexible learning aiming for the ability-based performances. To be a real intelligence neuroscientist or cognitive neuroscientist, you might need specialized ability-based performance and fund-included web-platform instead of a doctoral degree or post-doctoral medical background, or some professional training certificates or qualifications. "Learning and improving oneself is a life-long course. To be earnest, degrees and diplomas or occupational certificates or qualifications, even the web courses are totally not necessary to the research, even in the future. Internet, specialized e-contents and the interest for the research, including the practicing and webforum, is necessary." from one poster in this forum.
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