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> Extracellular Neurophysiology, Difficulties in understanding some phrases
mit_cool
post Apr 26, 2013, 04:05 AM
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I am reading one papaer about spike sorting method and I found one phrase and It is difficult for me to understand.
So can any one explain me how they decided number of neurons which fires 60 n 70 v and also 10V.
Thanks in advance



Approximating the neuron by a dipole source, following Coulomb’s law
the amplitude decays as v∼1/r^2, as a function of the distance. We
can also consider that spikes of about 60 V are produced by neurons
at a distance of about 50 m – the maximum distance (and
minimum amplitude) at which single units are identified (Buzsaki,
2004). Taking a density of 300,000 neurons/mm3 (as in the rat hippocampus;
Henze et al., 2000), it immediately follows that there
should be more than 30 neurons firing spikes with an amplitude
between 60 and 70 V, at the threshold of single unit detection,
and about 10 neurons firing (relatively large) spikes, within 100
and 110 V. So, within a small amplitude range of 10 V there
are several neurons whose spikes could hardly be separated by
their amplitudes (i.e. using a spike sorter based on amplitude discrimination)
given the background noise. It is also likely that more
sophisticated spike sorters that extract features of the spike shapes
(beyond their amplitude) will also miss at least some of these neurons,
as we report below.
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