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> Most potent Brain enhancement and Focus
post Jan 16, 2015, 07:15 PM
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Hi all,
Can someone please recommend for me the MOST potent brain enhancement and mood improvement stacks. I am really looking for results and I want something as potent as adderall but won't deny me sleep. Please help!
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post Jan 17, 2015, 04:29 AM
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QUOTE(Majormuss @ Jan 16, 2015, 04:15 PM) *

Hi all,
Can someone please recommend for me the MOST potent brain enhancement and mood improvement stacks. I am really looking for results and I want something as potent as adderall but won't deny me sleep. Please help!

It looks like you're looking for something with acute effects, which would be something like modafinil, adrafinil, fluorenol, etc... but those aren't recommended for daily use and are mostly just eugeroics/wakefulness enhancers. Or some of the potent racetrams (pramiracetam, phenylpiracetam, oxiracetam, aniracetam, piracetam, and noopept). To build a stack, pick some racetams, acetylcholine precursors, amino acids, natural herbs, and other thing substances that suit your needs. Don't forget your diet, exercise, sleep, and basic nutritional supplements first.

There's lots of threads loaded with information that cover this. And remember everyone's biochemistry is different so you'll just have to test different nootropics out for yourself to determine which work best with you.

There was a thread that seems like it's what you're looking for, but I can't post links yet... So I will copy and paste the entire thread below:

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You may not be aware of it, but academic steroids are real, completely legal, and clinically proven. I have spent the last 10 months researching, purchasing, and experimenting with nearly every single nootropic available. (wiki nootropics) The effects have been profound. First, with the help of a little caffeine, I am able to study for the bar exam all day with zero mental fatigue. Second, I am able to read vast quantities of information only one time and spit it back with pinpoint precision. It is the closest thing to a photographic memory I have ever experienced. The information is just there on command when needed. When I take practice tests most days I have nearly perfect recall and my only mistakes are analysis.

You can do this for yourself.

The following nootropic regimen is unique in a few regards.

First, the effects of the supplements are synergistic because each of them has a different mechanism of action. If you randomly start taking nootropics, you are likely to take supplements that do not give you a synergistic effect. For instance, acetylcholine is the primary nerotransmitter related to information processing. Acetylcholinerase is responsible for the breakdown of acetylcholine. There are multiple supplements that will increase acetylcholine production, among them CDPCholine, alphaGPC, DMAE, centrophenoxine and Acetyl L Carnitine. If you double up, you simply hit a ceiling on the amount of acetylcholine available. Also, many nootropics such as huperzine A inhibit acetylcholinerase. Inhibiting acetylcholinerase has the same effect as producing more acetylcholine. There are so many supplements whose only mechanism of action is either to increase acetylcholine production or inhibit acetylcholinerase. If you take multiples of these supplements, you will hit a ceiling and will not get a synergistic effect. The synergistic effect of different mechanisms of action is very important to the following regimen.

Second, the effects are cumulative. Caffeine and amphetamines actually deplete your brain over time. They are short-term band-aid solutions that merely shift your brain into overdrive before wearing it out. The supplements here actually enhance the structure and function of your brain. They are proven to be more effective in three months than they are when you first start taking them.

Third, these supplements are non-toxic. They are safe for chronic use.

Forth, if you start with the first three supplements to get a taste of what is available, it is relatively cheap.

If you are just getting started I recommend three supplements.

1) Piracetam 4g in the morning
2) CDPcholine 800mg in the morning
3) Either sulbutiamine or pyritinol

Piracetam is the time honored granddadday of all nootropics. When discovered it shocked researchers by being completely non-toxic and also enhancing the performance of normal adults with no forms of mental impairment. Piracetam is proven to increase performance on multiple measures of intelligence. Its effects are cumulative.

It is recommended that you take a source of choline with piracetam. I recommend CDPCholine. Piracetam needs a source of choline because acetylcholine is the primary neurotransmitter related to information processing.

Sulbutiamine prevents mental fatigue. You can be as effective 8 hours in to your day as you are upon waking up. Pyritinol increases alertness, energy and the ability to concentrate. Pick either.

The blood-brain barrier is a threshold that any nutrient must cross in order to be used by your brain. Sulbutiamine is a synthesized version of thiamine that crosses the blood-brain barrier better than regular thiamine. After crossing the blood-brain barrier it is broken down into two parts normal thiamine. It is essentially a brain specific source of thiamine. Thiamine reserves play an important role in mental endurance.

Pyritinol is a neuroenhanced version of vitamin B6. It is one of the oldest and safest nootropics available. Like sulbutiamine, it is essentially a brain specific version of a B vitamin.

I also take the following supplements.

Lion's Mane ~500mg in the morning ~500mg at bedtime to get an even distribution of constant NGF release
400mg Pyritinol in the morning
5g fish oil in the morning
150mg picamilon in the morning
500 mg phosphatydlserine matrix with 100mg PS, also including some phosphatydlcholine
1g sulbutiamine in the morning with whole milk
750mg aniracetam in the morning with whole milk
1g bacopa in the morning

Picamilion is a designer drug. GABA is a neurotransmitter that plays a role in reducing nervous excitement. However, taking GABA orally is ineffective because GABA cannot cross the blood-brain barrier. Picamilion is a synthesis of niacin (vitamin B3) and GABA that was designed to cross the blood-brain barrier. After crossing the blood-brain barrier picamilion is broken down to niacin and GABA.

I especially like the effect of the three neuroenhanced B vitamins. Sulbutiamine is broken down to two thiamine parts (vitamin B1) after crossing the blood-brain barrier. Picamilon is broken down to niacin (vitamin B3) and GABA after it crosses the blood-brain barrier. Pyritinol is enhanced B6. The combination of brain specific B1, B3 and B6 is greater than any of them alone. They are highly synergistic.

Aniracetam is a supplement derived from piracetam. It is much more potent that piracetam and has entirely different types of effects. I take 750 mg of aniracetam and 4000 mg of piracetam daily. The effects are synergistic. Aniracetam is another supplement that you should probably research for yourself. Any supplement in the -racetam family is entirely non-toxic, has cumulative effects, and impacts almost every known measure of mental performance.

Lion's mane is a mushroom that has been used for centuries in the east to enhance the nervous system. Recently it has been discovered that this is because lion's mane increases the production of Nerve Growth Factor. NGF is responsible for determining the rate at which new brain cells are produced. A Nobel Prize was awarded for this discovery because no other substance is known to cross the blood-brain barrier and stimulate the production of NGF. Six months of supplementation with lion's mane is proven to produce a significant improvement in nearly every measure of mental function in people with dementia. In a literal sense, you have more brains when you supplement with lion's mane. NOBEL-FREAKING-PRIZE. Don't underestimate it.

Phosphatidylcholine is synthesized from uridine, choline, and DHA. Fish Oil has two omega-3 fatty acids: EPA and DHA. CDPCholine is broken down and converted into uridine and choline. Thus, phosphatidylcholine can be produced from supplementation with CDPcholine and fish oil. Both phosphatydlcholine and phosphatidylserine are essential components of every nerve cell membrane. Increasing the levels of phosphatidylcholine and phosphatidylserine improve nearly every measure of mental performance.

Bacopa is a herbal supplement long used in India to enhance memory. It has unique chemicals that have a mechanism of action distinct from every other supplement in this regimen. Even alone it has a powerful effect on memory recall. It also repairs old and damaged neurons and dendrites. An interesting side effect is that it is as effective at reducing anxiety as prescription anti-anxiety medicines. This effect cannot be underestimated on stressful tests.

Finally, exercise is crucial. Exercise ensures that new neurons produced are able to perform under stress. It gives you a higher level of cognitive function naturally.

This is the holy grail of nootropic supplementation. If you go with the cheapest suppliers on the internet, you shouldn't be set back more than $100 a month. $3 a day is what it costs for limitless mental endurance and the best memory your brain is capable of having. You will surprise yourself. I promise you that you do not know how smart you really are.

As a side note, a doctor diagnosed me with ADHD and prescribed me Adderall. I think most ADHD diagnoses are bogus, but I still took Adderall because it was so effective at helping me to study. I still have a prescription for Adderall but I have stopped taking it. I literally experience almost no effect from it. With this regimen, it is as if I am always on Adderall already. Don't get me wrong. I WISH Adderall worked in conjunction with everything else. But the only effect it has on me now is making me obsessively organize and clean my room.

In addition to increasing performance on a variety of mental tasks, many of these supplements are proven effective at reversing alcohol related cognitive impairment. A year ago my short-term memory and ability to concentrate were impaired from all the drinking I did in law school. Today I can safely say that I am the smartest I have ever been. This will work for anybody.

Do your own research. You will only verify with I have told you.

If you start taking other supplements, the odds are you are only going to compound an effect already produced by one of the supplements on this list. They will not be synergistic. If you are really aggressive about nootropics with synergistic mechanisms of action, you can also look in to deprenyl, hydergine, lithium orotate and ashagandha. I take deprenyl and hydgergine off and on, but they are expensive enough that I do not include them in my usual nootropic stack. I caution against lithium orotate unless you know exactly what you're doing because it can be dangerous.

Good luck.

Note: Every person's brain biochemistry is different. There are a certain number of people who do not respond to Piracetam at all. The effect of any one of these supplements might be different for you. There is ultimately no substitute for researching and experimenting to find out what works for you.

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I don't take pyritinol because of the the possible side effects of the liver damage, but if you do take it just cycle it. I also only take sulbutiamine at 400mg 4x/week. He also says this in the comments:

"I don't cycle my sulbutiamine. I don't understand how you can develop a tolerance to a vitamin. That said, I haven't really tested whether a tolerance builds up by abstaining for a couple of days just to see. It seems to help me every day. I take about 1g per day. The liver damage is a real problem, which is why I only plan to take pyritinol for a couple of months. Use caution."

Ok and here is another post copy and pasted with some more useful information. It may not be the most potent stack but it is a good solid safe foundation. By mban:

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When looking at the brain and human memory you have to consider a variety of things which increase the ability to store, process, and recall information:

1) Cerebral blood flow - Neurons require large portions of our bodily blood flow to function effectively. More blood flow equates to increased oxygenation, which is required for energy formation from the powerhouse of our cells, mitochondria, when needed. More blood flow also increases nutrient and protein availability in order to express brain relevant genes and help in the conversion of precursor nutrients into relevant molecules that are required for optimal brain processing.

2) Adequate supply of nutrients required for the formation of neurotransmitters - these include amino acids such as tyrosine (precursor to adrenaline/epinephrine, noradrenaline/norepinephrine and dopamine), tryptophan (precursor to serotonin), acetyl-CoA and choline (precursors to acetylcholine formation), etc. Sufficient vitamins/minerals/nutrients are also needed as co-factors in many cellular reactions that are used to clear out debris from inside of our cells, and maintain proper cell functioning. Glucose is the primary food source for neurons of the brain. Better glucose regulation leads to better brain functioning (i.e. eat right and exercise to avoid diabetes - diabetes messes with brain functioning!).

3) A large supply of antioxidants - When parts of your brain are very active then generate large quantities of reactive oxygen species (ROS) which go on to damage cellular proteins, cell membranes, etc. Antioxidants act to "mop up" these ROS and prevent their eventual "brain fog" causing properties. Phytonutrients (e.g. from blueberries) can also help to make cells in our body produce more of our own "endogenous" anti-oxidants, which are best at countering ROS and keeping brain cells happy and firing.

4) Excitability level - Neurons only send transmission after they have received enough activation in order to "fire" and send on their signal. The most prevalent source of excitation for cerebral cortex neurons is through activation of glutamate channels by glutamate neurotransmitter. This excitation is mainly opposed by GABA and glycine neurotransmitters acting on GABA and Glycine channels, respectively, which effectively blunt the signal as they are inhibitory. The brain requires the precise and correct combination of excitation and inhibition in order to work optimally. Both too much excitation, or too much inhibition and the system will not function at its best.

5) Levels of neuronal branching - Neurons receive signals primarily through their dendrites, which are like the arms of a tree. If a neuron is very healthy it will be more branched, and the more branched the more information the system can hold (more connections between concepts are able to be formed).

6) Metabolic health - Neurons, as cells, are required to produce large amounts of ATP (the energy molecule of the cell). Sufficient production of ATP is needed in order to sustain neuron activity for prolonged amounts of time. ATP is broken down during use into ADP and AMP, which can signal to the cell that it is tired and needs to rest. If you can recycle ADP and AMP back into ATP faster, then the brain thinks it is less tired and can maintain high activity for longer.

Alright, now that you have a little background letís get in to what to do to boost brain function. Here are the basics first:

A) A general multivitamin (best/cheapest I find is LifeExtension's 2 per day multi's) - Provide you with the general nutrients to manufacture brain chemicals.

cool.gif Get plenty of exercise - While not a nootropic pill per say, this is one of the best for increasing levels of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), both of which increase the amount of dendrite branching and increase connections between difficult concepts, which helps with memory and with solving problems. Also, exercise helps with maintaining blood vessel elasticity and compliance so that blood flow can be better directed to different parts of the body when needed (i.e. makes the blood vessels of the brain more responsive to changes in neuron activity, and therefore helps neurons become more efficient at getting nutrients and functioning at their maximal capacity). Exercise also stresses cells, and makes them decide to clean out cellular junk/debris so that they function more efficiently. Further, it helps neurons build up a tolerance for functioning at high capacity with lower levels of available resources (neurons can adapt to exercise over time by becoming more resistant to becoming tired - means that you can study for longer without feeling as tired and without getting as much brain fog).

C) Get 7-10 hours of sleep a night - helps with keeping neuron energy stores high and promotes larger brain levels of NGF and BDNF. Proper rest, and a consistent sleep-wake schedule, can be the most effective "nootropic" that most people can give their bodies. The recommended amount of sleep for most adults is 8 hours, but if you need more for functioning best; work it into your schedule.

After you have those ones down pact, here are certain supplements/drugs/herbs that will help you out. Take all on an empty stomach. All separate doses should be taken 4-6 hours apart. Do not take less than 4 hours before bed:

D) Coenzyme Q10 + Bioperine - Aids in ATP production in cells. Bioperine, which is usually found combined with CoQ10 helps with absorption of many different nootropics - recommend 100-200mg CoQ10 per day divided between 2 separate doses

E) Acetyl L Carnitine (ALCAR) - Acts as an acetyl donor in the formation of acetylcholine. Helps transport fatty acids across the mitochondrial cell membrane to be used in the production of ATP. Increases receptors for NGF - Take 200-500mg, divided into 2 equal doses per day

F) CDP-choline - act as the choline donor in the formation of acetylcholine - take up to 500mg per day, divided into 2 doses

G) Ginkgo biloba - Increases cerebral blood flow and acts as a antioxidant. - Use 50-100mg, divided into 2 separate doses

H) Rhodiola Rosea and Eleuthero - These ones have pretty complex mechanisms of action, but in short they acts to reduce stress from long study hours, increase attention, act as antioxidants, boost levels of synaptic neurotransmitters or act directly on neurotransmitter receptors. They have a primary function of acting as "adaptogens" which help the body adapt to long periods of stress. They increase the amount of time that you can concentrate on a task at hand without becoming too tired to continue studying from the stress. I recommend relatively low doses of these when combined together and when taken with the other supplements on this list. Rhodiola Rosea - 50-200mg, Eleuthero - 100-300mg. Divide all of these into 2 separate doses.

I) Omega 3 fatty acids - Help with cell membrane stability, increases ability to concentrate and relieves stress over the long term. - Take up to five capsules per day.

J) Creatine monohydrate - Take 2 grams per day, PLUS 2-5 grams right before a big study session. Creatine plays a role within the cell of acting as a temporary energy carrier (as phosphocreatine), and is able to help replenish cellular levels of ATP by donating a phosphate group to ADP.



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There's some solid starter stacks, there's a lot more information online. You'll have to research and experiment for yourself. Good luck!

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post Nov 24, 2015, 08:25 AM
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Vitamin C- A combination of this vitamin with vitamin E helps to protect the brain and clear free radicals. Both vitamins safeguard the cells of the brain against glutamic acid.
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post Jan 03, 2016, 09:37 AM
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Yes Go and see Alpha Brain.
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